The multi-pass transmembrane protein ACCELERATED CELL DEATH 6 (ACD6) is an immune regulator in Ara-bidopsis thaliana with an unclear biochemical mode of action. We have identified two loci, MODULATOR OF HYPERACTIVE ACD6 1 (MHA1) and its paralog MHA1-LIKE (MHA1L), that code for-7 kDa proteins, which differentially interact with specific ACD6 variants. MHA1L enhances the accumulation of an ACD6 complex, thereby increasing the activity of the ACD6 standard allele for regulating plant growth and defenses. The intracellular ankyrin repeats of ACD6 are structurally similar to those found in mammalian ion channels. Several lines of evidence link increased ACD6 activity to enhanced calcium influx, with MHA1L as a direct regulator of ACD6, indicating that peptide-regulated ion channels are not restricted to animals.

We present optical, infrared, ultraviolet, and radio observations of SN 2022xkq, an underluminous fast-declining Type Ia supernova (SN Ia) in NGC 1784 (D approximate to 31 Mpc), from <1 to 180 days after explosion. The high-cadence observations of SN 2022xkq, a photometrically transitional and spectroscopically 91bg-like SN Ia, cover the first days and weeks following explosion, which are critical to distinguishing between explosion scenarios. The early light curve of SN 2022xkq has a red early color and exhibits a flux excess that is more prominent in redder bands; this is the first time such a feature has been seen in a transitional/91bg-like SN Ia. We also present 92 optical and 19 near-infrared (NIR) spectra, beginning 0.4 days after explosion in the optical and 2.6 days after explosion in the NIR. SN 2022xkq exhibits a long-lived C i 1.0693 mu m feature that persists until 5 days post-maximum. We also detect C ii lambda 6580 in the pre-maximum optical spectra. These lines are evidence for unburnt carbon that is difficult to reconcile with the double detonation of a sub-Chandrasekhar mass white dwarf. No existing explosion model can fully explain the photometric and spectroscopic data set of SN 2022xkq, but the considerable breadth of the observations is ideal for furthering our understanding of the processes that produce faint SNe Ia.

The connection between galaxies and dark matter halos is often quantified using the stellar mass-halo mass (SMHM) relation. Optical and near-infrared imaging surveys have led to a broadly consistent picture of the evolving SMHM relation based on measurements of galaxy abundances and angular correlation functions. Spectroscopic surveys at z greater than or similar to 2 can also constrain the SMHM relation via the galaxy autocorrelation function and through the cross-correlation between galaxies and Ly alpha absorption measured in transverse sight lines; however, such studies are very few and have produced some unexpected or inconclusive results. We use similar to 3000 spectra of z similar to 2.5 galaxies from the Ly alpha Tomography IMACS Survey (LATIS) to measure the galaxy-galaxy and galaxy-Ly alpha correlation functions in four bins of stellar mass spanning 10(9.2) less than or similar to M-*/M-circle dot less than or similar to 10(10.5). Parallel analyses of the MultiDark N-body and ASTRID hydrodynamic cosmological simulations allow us to model the correlation functions, estimate covariance matrices, and infer halo masses. We find that results of the two methods are mutually consistent and broadly accord with standard SMHM relations. This consistency demonstrates that we are able to measure and model Ly alpha transmission fluctuations delta(F) in LATIS accurately. We also show that the galaxy-Ly alpha cross-correlation, a free by-product of optical spectroscopic galaxy surveys at these redshifts, can constrain halo masses with similar precision to galaxy-galaxy clustering.

The search for definitive biosignatures-unambiguous markers of past or present life-is a central goal of paleobiology and astrobiology. We used pyrolysis-gas chromatography coupled to mass spectrometry to analyze chemically disparate samples, including living cells, geologically processed fossil organic material, carbon-rich meteorites, and laboratory-synthesized organic compounds and mixtures. Data from each sample were employed as training and test subsets for machine-learning methods, which resulted in a model that can identify the biogenicity of both contemporary and ancient geologically processed samples with similar to 90% accuracy. These machine-learning methods do not rely on precise compound identification: Rather, the relational aspects of chromatographic and mass peaks provide the needed information, which underscores this method's utility for detecting alien biology.

For the first time on Mars, the crystalline magnesium-sulfate mineral starkeyite (MgSO4 center dot 4H(2)O) was definitively identified using the CheMin X-ray diffraction instrument at Gale crater. At the Canaima drill site, starkeyite along with amorphous MgSO4 center dot nH(2)O are among the "polyhydrated Mg-sulfates" interpreted in orbital reflectance spectra. Mg-sulfates are good climate indicators as they are very responsive to changes in temperature and relative humidity. We hypothesize that, through evaporation, Mg-sulfates formed at the end of brine evolution when ion concentrations became saturated and precipitated on the surface or near sub-surface as either epsomite or meridianiite. These minerals were subsequently dehydrated later to starkeyite and amorphous MgSO4 center dot nH(2)O in response to a drier Mars. At Canaima, starkeyite is stable and would form during the warmer Mars summers. Due to very slow kinetics at the low Mars winter temperatures, starkeyite and amorphous MgSO4 center dot nH(2)O would be resistant to recrystallize to more hydrous forms and thus likely persist year-round. During the course of analyses, starkeyite transforms into amorphous MgSO4 center dot nH(2)O inside the rover body due to the elevated temperature and greatly reduced relative humidity compared to the martian surface at the Canaima drill site. It is possible that crystalline sulfate minerals existed in earlier samples measured by CheMin but altered inside the rover before they could be analyzed. Starkeyite is most likely prevalent in the subsurface, whereas both starkeyite and amorphous MgSO4 center dot nH(2)O are likely present on the surface as starkeyite could partially transform into amorphous MgSO4 center dot nH(2)O due to direct solar heating.

The origin of Earth's volatile elements is highly debated. Comparing the chalcogen isotope ratios in the bulk silicate Earth (BSE) to those of its possible building blocks, chondritic meteorites, allows constraints on the origin of Earth's volatiles; however, these comparisons are complicated by potential isotopic fractionation during protoplanetary differentiation, which largely remains poorly understood. Using first-principles calculations, we find that core-mantle differentiation does not notably fractionate selenium and tellurium isotopes, while equilibrium evaporation from early planetesimals would enrich selenium and tellurium in heavy isotopes in the BSE. The sulfur, selenium, and tellurium isotopic signatures of the BSE reveal that protoplanetary differentiation plays a key role in establishing most of Earth's volatile elements, and a late veneer does not substantially contribute to the BSE's volatile inventory.

We present a detailed chemical abundance analysis of the brightest star in the ultrafaint dwarf (UFD) galaxy candidate Cetus II from high-resolution Magellan/MIKE spectra. For this star, DES J011740.53-173053, abundances or upper limits of 18 elements from carbon to europium are derived. Its chemical abundances generally follow those of other UFD galaxy stars, with a slight enhancement of the alpha-elements (Mg, Si, and Ca) and low neutron-capture element (Sr, Ba, and Eu) abundances supporting the classification of Cetus II as a likely UFD. The star exhibits lower Sc, Ti, and V abundances than Milky Way (MW) halo stars with similar metallicity. This signature is consistent with yields from a supernova originating from a star with a mass of similar to 11.2 M-circle dot. In addition, the star has a potassium abundance of [K/Fe] = 0.81, which is somewhat higher than the K abundances of MW halo stars with similar metallicity, a signature that is also present in a number of UFD galaxies. A comparison including globular clusters and stellar stream stars suggests that high K is a specific characteristic of some UFD galaxy stars and can thus be used to help classify objects as UFD galaxies.

It has been suggested that beta Pic b has a supersolar metallicity and subsolar C/O ratio. Assuming solar carbon and oxygen abundances for the star beta Pic and therefore the planet's parent protoplanetary disk, beta Pic b's C/O ratio suggests that it formed via core accretion between its parent protoplanetary disk's H2O and CO2 ice lines. However, beta Pic b's high metallicity is difficult to reconcile with its mass M-p = 11.7 M-Jup. Massive stars can present peculiar photospheric abundances that are unlikely to record the abundances of their former protoplanetary disks. This issue can be overcome for early-type stars in moving groups by inferring the elemental abundances of the FGK stars in the same moving group that formed in the same molecular cloud and presumably share the same composition. We infer the photospheric abundances of the F dwarf HD 181327, a beta Pic moving group member that is the best available proxy for the composition of beta Pic b's parent protoplanetary disk. In parallel, we infer updated atmospheric abundances for beta Pic b. As expected for a planet of its mass formed via core-accretion beyond its parent protoplanetary disk's H2O ice line, we find that beta Pic b's atmosphere is consistent with stellar metallicity and confirm that it has superstellar carbon and oxygen abundances with a substellar C/O ratio. We propose that the elemental abundances of FGK dwarfs in moving groups can be used as proxies for the otherwise difficult-to-infer elemental abundances of early-type and late-type members of the same moving groups.

We present the stellar mass-stellar metallicity relation for 3491 star-forming galaxies at 2 less than or similar to z less than or similar to 3 using rest-frame far-ultraviolet spectra from the Ly alpha Tomography IMACS Survey (LATIS). We fit stellar population synthesis models from the Binary Population And Spectral Synthesis code (v2.2.1) to medium-resolution (R similar to 1000) and high signal-to-noise (>30 per 100 km s(-1) over the wavelength range 1221-1800 & Aring;) composite spectra of galaxies in bins of stellar mass to determine their stellar metallicity, primarily tracing Fe/H. We find a strong correlation between stellar mass and stellar metallicity, with stellar metallicity monotonically increasing with stellar mass at low masses and flattening at high masses (M-* greater than or similar to 10(10.3)M(circle dot)). Additionally, we compare our stellar metallicity measurements with the gas-phase oxygen abundance of galaxies at similar redshift and estimate the average [alpha/Fe] similar to 0.6. Such high alpha-enhancement indicates that high-redshift galaxies have not yet undergone significant iron enrichment through Type Ia supernovae. Moreover, we utilize an analytic chemical evolution model to constrain the mass loading parameter of galactic winds as a function of stellar mass. We find that as the stellar mass increases, the mass loading parameter decreases. The parameter then flattens or reaches a turning point at around M-* similar to 10(10.5)M(circle dot). Our findings may signal the onset of black-hole-driven outflows at z similar to 2.5 for galaxies with M-* greater than or similar to 10(10.5) M-circle dot.