Dr. Eric Isaacs Begins as 11th President of the Carnegie Institution for Science

Dr. Eric D. Isaacs begins his tenure as the 11th president of the Carnegie Institution on July 2, 2018.  Isaacs joins Carnegie from the University of Chicago where he has been the Robert A. Millikan Distinguished Service Professor, Department of Physics and the James Franck Institute Executive Vice President for Research, Innovation and National Laboratories. 

 

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  • How much of a reef’s ability to withstand stressful conditions is influenced by the type of symbiotic algae that its corals hosts? New work from a team including Carnegie's Arthur Grossman investigates how the the abundance and diversity of nutrients that algae share with their coral  hosts varies between species and what this could mean for coral’s ability to survive in a changing climate.  The research team determined that in the wake of a bleaching event, even an algal tenant that’s poor provider may be better than no provider.

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    Earthquakes, floods, tsunamis, hurricanes, and volcanoes—they all stem from the very same forces that give our planet life. It is only when these forces exceed our ability to withstand them that they become disasters. Science and engineering can be used to understand extreme events and to design our cities to be resilient, but we must overcome the psychological drive to normalization that keeps humanity from believing that we could experience anything worse than what we have already survived.

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The interactions that take place between the species of microbes living in the gastrointestinal system often have large and unpredicted effects on health, according to new work led by Carnegie’s Will Ludington, who assembled a team of biologists, physicists, and mathematicians to comprehensively reveal the gut microbiome ecosystem of fruit flies. 

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A supernova discovered by an international group of astronomers including Carnegie’s Tom Holoien and Maria Drout, and Carnegie alumnus Ben Shappee of the University of Hawaii, provides an unprecedented look at the first moments of a violent stellar explosion. The light from the explosion's first hours showed an unexpected pattern, which Carnegie's Anthony Piro analyzed to reveal that the genesis of these phenomena is even more mysterious than previously thought.

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Carnegie’s Anna Michalak was a major contributor to the U.S. Global Change Research Program’s Second State of the Carbon Cycle Report released last Friday, which provides a current state-of-the-science assessment of the carbon cycle in North America—including the United States, Canada, and Mexico—and  its connection to climate and society.

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An international team including five Carnegie astronomers has discovered a frozen Super-Earth orbiting Barnard’s star, the closest single star to our own Sun. The Planet Finder Spectrograph on Carnegie’s Magellan II telescope was integral to the discovery, which is published in Nature. To find this cold Super-Earth, the team combined 20 years of data from seven different instruments, all of which were “stitched” together to form one of the largest and most-extensive datasets ever used for this method of planet detection.

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  • Almost half of our DNA is made up of jumping genes, moving around the genome in developing sperm and egg cells. Given their ability to jump around the genome, their invasion can trigger DNA damage and mutations often leading to animal sterility or even death and threatening species survival. Organisms have survived these invasions, but little is known about where this adaptability comes from. Now, Carnegie researchers have discovered that reproductive stem cells boost production of non-coding RNA elements that suppress jumping gene activity and activate a DNA repair process allowing for normal egg development. 

     

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Fifty years ago, Americans led the world in math and science, claiming some of the most important inventions and technological breakthroughs of the 20th century.  Today, American 15-year-olds rank 25th in math compared to their peers worldwide.  Math ƒor America DC strives to reclaim...
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CALL FOR PROPOSALS Following Andrew Carnegie’s founding encouragement of liberal discovery-driven research, the Carnegie Institution for Science offers its scientists a new resource for pursuing bold ideas. Carnegie Science Venture grants are internal awards of up to $100,000 that are...
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In mammals, most lipids, such as fatty acids and cholesterol, are absorbed into the body via the small intestine. The complexity of the cells and fluids that inhabit this organ make it very difficult to study in a laboratory setting. The goal of the Farber lab is to better understand the cell and...
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Tuesday, December 11, 2018 - 6:30pm to 7:45pm

HABITABILITY: WHAT EARTH AND THE INNER PLANETS CAN TEACH US ABOUT THE SEARCH FOR LIFE ON ROCKY EXOPLANETS
What enabled life to form on Earth—and what kept it at bay on...

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Cosmochemist Larry Nittler studies extraterrestrial materials, including meteorites and interplanetary dust particles (IDPs), to understand the formation of the Solar System, the galaxy, and the universe and to identify the materials involved. He is particularly interested in developing new...
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The Donald Brown laboratory uses  amphibian metamorphosis to study complex developmental programs such as the development of vertebrate organs. The thyroid gland secretes thyroxine (TH), a hormone essential for the growth and development of all vertebrates including humans. To understand TH,...
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Scott Sheppard studies the dynamical and physical properties of small bodies in our Solar System, such as asteroids, comets, moons and trans-neptunian objects (bodies that orbit beyond Neptune).  These objects have a fossilized imprint from the formation and migration of the major planets in...
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A bright field image of the anemone Aiptasia populated with its symbiotic algae.
December 6, 2018

Stanford, CA—How much of the ability of a coral reef to withstand stressful conditions is influenced by the type of algae that the corals hosts?

Corals are marine invertebrates from the phylum called cnidarians that build large exoskeletons from which colorful reefs are constructed. But this reef-building is only possible because of a mutually beneficial relationship between the coral and various species of single-celled algae called dinoflagellates that live inside the cells of coral polyps.

The algae are photosynthetic—meaning capable of converting the Sun’s energy into chemical energy for food, just like plants. And the exchange of nutrients between the

Super-resolution image of fly gut crypts colonized by the native Lactobacillus (red) and Acetobacter (green) bacteria. Fly cell nuclei appear blue. Image is courtesy of Benjamin Obadia.
December 4, 2018

Baltimore, MD—The interactions that take place between the species of microbes living in the gastrointestinal system often have large and unpredicted effects on health, according to new work from a team led by Carnegie’s Will Ludington. Their findings are published this week in Proceedings of the National Academy of Sciences.

The gut microbiome is an ecosystem of hundreds to thousands of microbial species living within the human body.  The sheer diversity within the human gut presents a challenge to cataloging and understanding the effect these communities have on our health.

Biologists are particularly interested in determining whether or not the

Pan-STARRS image showing the host galaxy of the newly discovered supernova ASASSN-18bt
November 29, 2018

Pasadena, CA—A supernova discovered by an international group of astronomers including Carnegie’s Tom Holoien and Maria Drout, and led by University of Hawaii’s Ben Shappee, provides an unprecedented look at the first moments of a violent stellar explosion. The light from the explosion's first hours showed an unexpected pattern, which Carnegie's Anthony Piro analyzed to reveal that the genesis of these phenomena is even more mysterious than previously thought.

Their findings are published in a trio of papers in The Astrophysical Journal and The Astrophysical Journal Letters. (You can read them here, here, and here.)

Type Ia supernovae are

SOCCR2 cover art
November 27, 2018

Washington, DC—Carnegie’s Anna Michalak was a major contributor to the U.S. Global Change Research Program’s Second State of the Carbon Cycle Report released last Friday, which provides a current state-of-the-science assessment of the carbon cycle in North America—including the United States, Canada, and Mexico—and  its connection to climate and society.

Over the past decade, fossil fuel emissions continued to be by far the largest North American carbon source. Urban areas in North America are the primary source of anthropogenic carbon emissions.

But land ecosystems and the ocean play a major role in removing and sequestering carbon

December 11, 2018

HABITABILITY: WHAT EARTH AND THE INNER PLANETS CAN TEACH US ABOUT THE SEARCH FOR LIFE ON ROCKY EXOPLANETS
What enabled life to form on Earth—and what kept it at bay on Mars and Venus? Does habitability demand factors like plate tectonics and magnetic fields? Will astronomers be able to detect hints of these processes on other worlds? UC Davis Earth planetary scientist and recently named MacArthur Fellow, Dr. Sarah Stewart, will give a short overview of the topic, and then join a panel of planet formation experts for a moderated discussion of the preconditions that make life possible—and the chances of finding it elsewhere.

Dr. Sarah Stewart: University of

The Carnegie Irvine Galaxy Survey is obtaining high-quality optical and near-infrared images of several hundred of the brightest galaxies in the southern hemisphere sky, at Carnegie’s Las Campanas Observatory to investigate the structural properties of galaxies. For more see    http://cgs.obs.carnegiescience.edu/CGS/Home.html

The Fan laboratory studies the molecular mechanisms that govern mammalian development, using the mouse as a model. They use a combination of biochemical, molecular and genetic approaches to identify and characterize signaling molecules and pathways that control the development and maintenance of the musculoskeletal and hypothalamic systems.

The musculoskeletal system provides the mechanical support for our posture and movement. How it arises during embryogenesis pertains to the basic problem of embryonic induction. How the components of this system are repaired after injury and maintained throughout life is of biological and clinical significance. They study how this system is

The Anglo-Australian Planet Search (AAPS) is a long-term program being carried out on the 3.9-meter Anglo-Australian Telescope (AAT) to search for giant planets around more than 240 nearby Sun-like stars. The team, including Carnegie scientists,  uses the "Doppler wobble" technique to search for these otherwise invisible extra-solar planets, and achieve the highest long-term precision demonstrated by any Southern Hemisphere planet search.

The Carnegie Airborne Observatory (CAO), developed by GregAsner, is a fixed-wing aircraft that sweeps laser light across the vegetation canopy to image it in brilliant 3-D. The data can determine the location and size of each tree at a resolution of 3.5 feet (1.1 meter), a level of detail that is unprecedented. By combining field surveys with this airborne mapping and high-resolution satellite monitoring the team has been able to detail myriad ecological features of forests around the world.

As one example, Carnegie scientists with the Peruvian Ministry of Environment mapped the true extent of gold mining in the biologically diverse region of Madre de Dios in the Peruvian Amazon.

Integrity of hereditary material—the genome —is critical for species survival. Genomes need protection from agents that can cause mutations affecting DNA coding, regulatory functions, and duplication during cell division. DNA sequences called transposons, or jumping genes (discovered by Carnegie’s Barbara McClintock,) can multiply and randomly jump around the genome and cause mutations. About half of the sequence of the human and mouse genomes is derived from these mobile elements.  RNA interference (RNAi, codiscovered by Carnegie’s Andy Fire) and related processes are central to transposon control, particularly in egg and sperm precursor cells.  

Rocks, fossils, and other natural relics hold clues to ancient environments in the form of different ratios of isotopes—atomic variants of elements with the same number of protons but different numbers of neutrons. Seawater, rain water, oxygen, and ozone, for instance, all have different ratios, or fingerprints, of the oxygen isotopes 16O, 17O, and 18O. Weathering, ground water, and direct deposition of atmospheric aerosols change the ratios of the isotopes in a rock revealing a lot about the past climate.

Douglas Rumble’s research is centered on these three stable isotopes of oxygen and the four stable isotopes of sulfur 32S , 33S , 34S, and 36S. In addition to

Director Emeritus, George Preston has been deciphering the chemical evolution of stars in our Milky Way for a quarter of a century. He and Steve Shectman started this quest using a special technique to conduct a needle-in-the-haystack search for the few, first-generation stars, whose chemical compositions sketch the history of element formation in the galaxy. These earliest stars are very rare and they are characteristically low in heavy metals because of their age. They were made of Big Bang material, mostly hydrogen and helium. It was only later that heavier elements were formed in the nuclear furnaces of newer stars.

 In their first study, Preston and Shectman compiled a

Frederick Tan holds a unique position at Embryology in this era of high-throughput sequencing where determining DNA and RNA sequences has become one of the most powerful technologies in biology. DNA provides the basic code shared by all our cells to program our development. While there are about 30,000 human genes, 98% of DNA sequences are comprised of repetitive and regulatory sequences within and between genes. Measuring the specific set of DNA sequences that are transcribed into RNA helps reveal what and how our tissues are doing by showing which genes are active.

Modern sequencing platforms, such as the Illumina HiSeq 2000, generate only short, ordered sequences, usually 100