SYNTHESIS OF NEW OPTICALLY-ACTIVE 1,3-DIOLS WITH CAMPHOR AND FENCHONE SKELETON

The new optically active 1,3-diols 5-8 with (1R)-(+)-camphor and (1R)-(-)-fenchone skeleton were synthesized in high yields from the homoallylic alcohols 1-4 using a very effective ozonolysis followed by reduction. The absolute configuration of (1R, 2S, 12R)-6a was determined by a single crystal X-ray study.