Peter Senchyna's work is centered on constraining the earliest generations of massive stars and the galaxies they shaped. To study these ancient times, Senchyna's work brings together observations of high-redshift galaxies caught in formation just after the Big Bang with deep observations of the nearby universe, including low-mass galaxies nearby that harbor short-lived massive stars and ionized gas under conditions approaching those that prevailed in the first half-billion years. Broadly, Senchyna is interested in the intersection between stellar and extragalactic astrophysics, and in leveraging observations across wavelengths (centered on rest-UV to optical spectroscopy) to improve our understanding of the most uncertain aspects of the evolution of and interplay between massive stars and galaxies.