Ribosome stalling leads to recruitment of the ribosome quality control complex (RQC), which targets the partially synthesized polypeptide for proteasomal degradation through the action of the ubiquitin ligase Ltn1p. A second core RQC component, Rqc2p, modifies the nascent polypeptide by adding a carboxyl-terminal alanine and threonine (CAT) tail through a noncanonical elongation reaction. Here we examined the role of CAT-tailing in nascent-chain degradation in budding yeast. We found that Ltn1p efficiently accessed only nascent-chain lysines immediately proximal to the ribosome exit tunnel. For substrates without Ltn1p-accessible lysines, CAT-tailing enabled degradation by exposing lysines sequestered in the ribosome exit tunnel. Thus, CAT-tails do not serve as a degron, but rather provide a fail-safe mechanism that expands the range of RQC-degradable substrates.

Thermoelectric generator composed of crystalline radical ion salts: The unipolar charge transport along the molecular stacks facilitates complementary p-and n-type organic thermoelectric materials of high electrical conductivity and of 1D electronic structure. The specific power output of 5 mW cm(-2) and the zT > 0.15 below 40 K demonstrate a new field of low-temperature thermoelectric applications unlocked by organic metals.

The addition of N-and S-functionalized organolithium compounds to (-)-menthone was studied and a series of new chiral substituted neomenthol derivatives has been isolated. The new chiral compounds have been applied as precatalysts for addition of diethylzinc to aldehydes and enantioselectivity of up to 80% ee was achieved.

Fabric formwork is an emerging method for casting concrete in flexible membranes, which offers unrivalled opportunities to create architectural structures, as well as to shape structural elements appropriately and use concrete more efficiently. Research studies of fabric-formed beams carried out at the University of Bath have indicated that a minimum of 40% material savings are achievable with optimised design of fabric-formed concrete. Practical design tools and construction guidance have also been developed as part of the research studies to encourage the industrial application of fabric formwork. Reinforcing fabric-formed elements with FRP composite materials has been investigated for the significant advantages it provides in terms of installation and manufacturing techniques suitable for concrete elements with varying geometry. This paper presents experimentally tested construction approaches, proposed design methodology and experimental results, which validate the design method and demonstrate the possibility to build FRP-reinforced fabric-formed beams exhibiting ductile behaviour.

An entry from the Cambridge Structural Database, the worlds repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

An entry from the Cambridge Structural Database, the worlds repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

A straightforward approach to the synthesis of two different series of cationic [5]helicenes has been achieved including, in dioxa series, the possibility to introduce aromatic functional groups at the periphery of the helical structure. While photophysical study highlights that the introduction of aryl substituents at position 23 of the helical moieties has a negligible impact on the optical properties, styryl substituents allow a welcoming extension of the conjugation pathways. Finally, a red shift of the optical properties was evidenced upon introduction of nitrogen atoms in the helicene scaffold, leading to particularly good fluorescence efficiencies in the red domain for a helicenic dye. Detailed information on racemization kinetics was collected for the most stable species upon direct high-performance liquid chromatography (HPLC) resolution or, when configurational lability was too high, through VT-HPLC analysis on the chiral stationary phase (DeltaG values ranging from 85.0 to 137.1 kJ·mol-1 and above). Copyright: CC BY-NC 4.0

An entry from the Cambridge Structural Database, the worlds repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

An entry from the Cambridge Structural Database, the worlds repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.