The Kostova Lab investigates the fundamental question of how cells respond when their ribosomes break down. The ribosome is one of the most complex and long-lived molecular machines in the cell, and the presence of functional ribosomes is essential to life. Ribosome damage has been recently linked to complex human diseases, such as cancer and neurodegeneration. We use cutting-edge technology, such as CRISPR-mediated genome editing and genome-scale screens, to model and map the molecular pathways that ensure ribosome integrity.