Stereoselective functionalization strategy of 2,5-diketopiperazine derived from L-proline and glycine

The functionalization of diketopiperazine Cyclo(Gly-Pro) by using suitable deprotonation reagent and electrophile offers the opportunity for synthesis of structurally diverse series of compounds (libraries) possessing bioactivity. This synthetic approach has been proved as feasible in respect to use different electrophiles and in particularly concerning the observed very high stereoselecitvity.