Baltimore, MD--BioEYES, the K-12 science education program headquartered at  Carnegie's Department of Embryology, was recognized with four other organizations by the General Motors...
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Baltimore, MD— As we age, the function and regenerative abilities of skeletal muscles deteriorate, which means it is difficult for the elderly to recover from injury or surgery. New work from...
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Baltimore, MD—New work from Carnegie’s Allan Spradling and Lei Lei demonstrates that mammalian egg cells gain crucial cellular components at an early stage from their undifferentiated...
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Washington, D.C.—Matthew Sieber, a postdoctoral fellow at the Department of Embryology, has been honored for his extraordinary accomplishments, through a new program that recognizes exceptional...
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Baltimore, MD— Reproduction is highly dependent on diet and the ability to use nutrients to grow and generate energy. This is clearly seen in women, who must provide all the nutritional...
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San Diego, CA— Ghosts are not your typical cell biology research subjects. But scientists at the Carnegie Institution for Science and the National Institute of Child Health and Human...
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The American Society for Cell Biology profiles Yixian Zheng and her recent papers on the elusive spindle matrix. "Zheng’s lab identifies new regulators in spindle assembly, all...
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Two researchers, Martin Jonikas of Carnegie’s Department of Plant Biology and Zhao Zhang of the Department of Embryology, have been awarded the New Innovator and Early Independence Awards,...
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The Spradling laboratory studies the biology of reproduction. By unknown means eggs reset the normally irreversible processes of differentiation and aging. The fruit fly Drosophila provides a favorable multicellular system for molecular genetic studies. The lab focuses on several aspects of egg...
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The Gall laboratory studies all aspects of the cell nucleus, particularly the structure of chromosomes, the transcription and processing of RNA, and the role of bodies inside the cell nucleus, especially the Cajal body (CB) and the histone locus body (HLB). Much of the work makes use of the giant...
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Approximately half of the gene sequences of human and mouse genomes comes from so-called mobile elements—genes that jump around the genome. Much of this DNA is no longer capable of moving, but is likely “auditioning”  perhaps as a regulator of gene function or in homologous...
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Brittany Belin joined the Department of Embryology staff in August 2020. Her Ph.D. research involved developing new tools for in vivo imaging of actin in cell nuclei. Actin is a major structural element in eukaryotic cells—cells with a nucleus and organelles —forming contractile...
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Steven Farber
In mammals, most lipids, such as fatty acids and cholesterol, are absorbed into the body via the small intestine. The complexity of the cells and fluids that inhabit this organ make it very difficult to study in a laboratory setting. The goal of the Farber lab is to better understand the cell and...
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Yixian Zheng is Director of the Department of Embryology. Her lab has a long-standing interest in cell division. In recent years, their findings have broadened their research using animal models, to include the study of stem cells, genome organization, and lineage specification—how stem cells...
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Recently published work from Carnegie’s Allan Spradling and Wanbao Niu revealed in unprecedented detail the genetic instructions immature egg cells go through step by step as they mature into...
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Recent work from Carnegie’s Chenhui Wang and Allan Spradling reveals a surprising capability of renal stem cells in fruit flies—remodeling. Their work, which could eventually guide kidney...
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Baltimore, MD—As animals age, their immune systems gradually deteriorate, a process called immunosenescence. It is associated with systemic inflammation and chronic inflammatory disorders, as well as...
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Explore Carnegie Science

Watercolor illustration of Drosophila, courtesy Carnegie Institution for Science
June 15, 2022

Baltimore, MD— Recent work from Carnegie’s Chenhui Wang and Allan Spradling reveals a surprising capability of renal stem cells in fruit flies—remodeling. Their work, which could eventually guide kidney stone treatments, was published by Science Advances.

Stem cells are the raw materials from which our bodies are formed.

The ultimate utility player, embryonic stem cells are capable of differentiating into any cell type to construct any organ or tissue in the body. Adult stem cells’ abilities are not quite so unlimited. They exist within a specific tissue—such as the skin or the intestinal lining—and are responsible for renewing it

Artist's conception by Navid Marvi
February 9, 2022

Baltimore, MD— The gut microbiome is an ecosystem of hundreds to thousands of microbial species living within the human body. These populations affect our health, fertility, and even our longevity. But how do they get there in the first place?

New collaborative work led by Carnegie’s William Ludington reveals crucial details about how the bacterial communities that comprise each of our individual gut microbiomes are acquired. These findings, published in the Proceedings of the National Academy of Sciences, have major implications for treatments such as fecal transplants and probiotic administration.

“There is a huge amount of variation in microbiome

Palm trees rise in front of the San Gabriel Mountains.
January 10, 2022

Washington, DC—California Governor Gavin Newsom on Monday announced $20 million in his 2023 fiscal year budget to support Carnegie’s new research facility in Pasadena. The proposed budget allocation still must clear the California State Senate and Assembly, which will begin to hold hearings in the coming weeks. It must be adopted by June 15. 

The new 135,000-square-foot, state-of-the-art campus will bring the institution’s life and environmental scientists together in a single location adjacent to Caltech—making a decisive investment in the global fight against climate change. The facility will house more than 200 new hires and relocated staff, who

Margaret McFall-Ngai
November 17, 2021

Washington, DC—Pioneering microbiome specialist Margaret McFall-Ngai has been named the inaugural director of Carnegie’s newly launched research division focused on life and environmental sciences, which will deploy an integrated, molecular-to-global approach to tackling the challenges of sustainability, resilience, and adaptation to a changing climate. McFall-Ngai will join the institution in January, 2022, from the University of Hawai‘i at Mānoa, where she is a professor at the Pacific Biosciences Research Center’s Kewalo Marine Laboratory and the center’s director emerita.

“Margaret’s exemplary research and groundbreaking vision are the

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The Spradling laboratory studies the biology of reproduction. By unknown means eggs reset the normally irreversible processes of differentiation and aging. The fruit fly Drosophila provides a favorable multicellular system for molecular genetic studies. The lab focuses on several aspects of egg development, called oogenesis, which promises to provide insight into the rejuvenation of the nucleus and surrounding cytoplasm. By studying ovarian stem cells, they are learning how cells maintain an undifferentiated state and how cell production is regulated by microenvironments known as niches. They are  also re-investigating the role of steroid and prostaglandin hormones in controlling

Approximately half of the gene sequences of human and mouse genomes comes from so-called mobile elements—genes that jump around the genome. Much of this DNA is no longer capable of moving, but is likely “auditioning”  perhaps as a regulator of gene function or in homologous recombination, which is a type of genetic recombination where the basic structural units of DNA,  nucleotide sequences, are exchanged between two DNA molecules to  repair  breaks in the DNA  strands. Modern mammalian genomes also contain numerous intact movable elements, such as retrotransposon LINE-1, that use RNA intermediates to spread about the genome. 

Given

The Gall laboratory studies all aspects of the cell nucleus, particularly the structure of chromosomes, the transcription and processing of RNA, and the role of bodies inside the cell nucleus, especially the Cajal body (CB) and the histone locus body (HLB).

Much of the work makes use of the giant oocyte of amphibians and the equally giant nucleus or germinal vesicle (GV) found in it. He is particularly  interested in how the structure of the nucleus is related to the synthesis and processing of RNA—specifically, what changes occur in the chromosomes and other nuclear components when RNA is synthesized, processed, and transported to the cytoplasm.

In mammals, most lipids, such as fatty acids and cholesterol, are absorbed into the body via the small intestine. The complexity of the cells and fluids that inhabit this organ make it very difficult to study in a laboratory setting. The goal of the Farber lab is to better understand the cell and molecular biology of lipids within digestive organs by exploiting the many unique attributes of the clear zebrafish larva  to visualize lipid uptake and processing in real time.  Given their utmost necessity for proper cellular function, it is not surprising that defects in lipid metabolism underlie a number of human diseases, including obesity, diabetes, and atherosclerosis.

Integrity of hereditary material—the genome —is critical for species survival. Genomes need protection from agents that can cause mutations affecting DNA coding, regulatory functions, and duplication during cell division. DNA sequences called transposons, or jumping genes (discovered by Carnegie’s Barbara McClintock,) can multiply and randomly jump around the genome and cause mutations. About half of the sequence of the human and mouse genomes is derived from these mobile elements.  RNA interference (RNAi, codiscovered by Carnegie’s Andy Fire) and related processes are central to transposon control, particularly in egg and sperm precursor cells.  

Steven Farber

In mammals, most lipids, such as fatty acids and cholesterol, are absorbed into the body via the small intestine. The complexity of the cells and fluids that inhabit this organ make it very difficult to study in a laboratory setting. The goal of the Farber lab is to better understand the cell and molecular biology of lipids within digestive organs by exploiting the many unique attributes of the clear zebrafish larva  to visualize lipid uptake and processing in real time.  Given their utmost necessity for proper cellular function, it is not surprising that defects in lipid metabolism underlie a number of human diseases, including obesity, diabetes, and atherosclerosis.

Staff Associate Kamena Kostova joined the Department of Embryology in November 2018. She studies ribosomes, the factory-like structures inside cells that produce proteins. Scientists have known about ribosome structure, function, and biogenesis for some time. But, a major unanswered question is how cells monitor the integrity of the ribosome itself. Problems with ribosomes have been associated with diseases including neurodegeneration and cancer. The Kostova lab investigates the fundamental question of how cells respond when their ribosomes break down using mass spectrometry, functional genomics methods, and CRISPR genome editing.

Kostova received a B.S. in Biology from the

Allan Spradling is a Howard Hughes Medical Institute Investigator and director emeritus of the Department of Embryology. His laboratory studies the biology of reproduction particularly egg cells, which are able to reset the normally irreversible processes of differentiation and aging that govern all somatic cells—those that turn into non-reproductive tissues. Spradling uses the fruit fly Drosophila because the genes and processes studied are likely to be similar to those in other organisms including humans. In the 1980s he and his colleague, Gerald Rubin, showed how jumping genes could be used to identify and manipulate fruit fly genes. Their innovative technique helped establish