Washington, D.C.—BioEYES was accepted to participate in a National Science Foundation (NSF) video competition on May 15-22, 2017. BioEYES supporters are encouraged to go to the competition...
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On Tuesday night, George Church told us that a fascination with animatronic Abraham Lincoln at the 1964 World’s Fair partially inspired him to become a scientist. This seems fitting, somehow,...
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Carnegie Science, Carnegie Institution, Carnegie Institution for Science
Baltimore, MD—Studying how our bodies metabolize lipids such as fatty acids, triglycerides, and cholesterol can teach us about cardiovascular disease, diabetes, and other health problems, as...
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People often call dogs “man’s best friend.” But after Elaine Ostrander’s presentation at our Washington, DC, headquarters Thursday, we think that moniker should probably be...
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Baltimore, MD—A first-of-its-kind study on almost 20,000 K-12 underrepresented public school students shows that Project BioEYES, based at Carnegie’s Department of Embryology, is...
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Carnegie Science, Carnegie Institution, Carnegie Institution for Science
Baltimore, MD— New work led by Carnegie’s Steven Farber, with help from Yixian Zheng’s lab, sheds light on how form follows function for intestinal cells responding to high-fat...
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Carnegie Science, Carnegie Institution, Carnegie Institution for Science
Baltimore, MD---Athletes, the elderly and those with degenerative muscle disease would all benefit from accelerated muscle repair. When skeletal muscles, those connected to the bone, are injured,...
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Washington, D.C.—  Zehra Nizami has been a graduate student and postdoc in Joe Gall’s lab at the Department of Embryology. She is the fourth recipient of the Postdoctoral Innovation...
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The Fan laboratory studies the molecular mechanisms that govern mammalian development, using the mouse as a model. They use a combination of biochemical, molecular and genetic approaches to identify and characterize signaling molecules and pathways that control the development and maintenance of...
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The Spradling laboratory studies the biology of reproduction. By unknown means eggs reset the normally irreversible processes of differentiation and aging. The fruit fly Drosophila provides a favorable multicellular system for molecular genetic studies. The lab focuses on several aspects of egg...
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Approximately half of the gene sequences of human and mouse genomes comes from so-called mobile elements—genes that jump around the genome. Much of this DNA is no longer capable of moving, but is likely “auditioning”  perhaps as a regulator of gene function or in homologous...
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Staff Associate Kamena Kostova joined the Department of Embryology in November 2018. She studies ribosomes, the factory-like structures inside cells that produce proteins. Scientists have known about ribosome structure, function, and biogenesis for some time. But, a major unanswered question...
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Allan Spradling is a Howard Hughes Medical Institute Investigator and director emeritus of the Department of Embryology. His laboratory studies the biology of reproduction particularly egg cells, which are able to reset the normally irreversible processes of differentiation and aging that govern...
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Frederick Tan holds a unique position at Embryology in this era of high-throughput sequencing where determining DNA and RNA sequences has become one of the most powerful technologies in biology. DNA provides the basic code shared by all our cells to program our development. While there are about 30...
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Tasuku Honjo, a postdoctoral fellow in the Brown Lab at the Department of Embryology 1971-1973 shares the 2018 Nobel Prize in Physiology or Medicine.  
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Matthew Sieber, a postdoctoral fellow at the Department of Embryology, has been honored for his extraordinary accomplishments, through a new program that recognizes exceptional Carnegie...
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Audio Baltimore, MD—In researching neural pathways, it helps to establish an analogous relationship between a region of the human brain and the brains of more-easily studied animal species. New work...
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Watercolor illustration of Drosophila, courtesy Carnegie Institution for Science
June 15, 2022

Baltimore, MD— Recent work from Carnegie’s Chenhui Wang and Allan Spradling reveals a surprising capability of renal stem cells in fruit flies—remodeling. Their work, which could eventually guide kidney stone treatments, was published by Science Advances.

Stem cells are the raw materials from which our bodies are formed.

The ultimate utility player, embryonic stem cells are capable of differentiating into any cell type to construct any organ or tissue in the body. Adult stem cells’ abilities are not quite so unlimited. They exist within a specific tissue—such as the skin or the intestinal lining—and are responsible for renewing it

Artist's conception by Navid Marvi
February 9, 2022

Baltimore, MD— The gut microbiome is an ecosystem of hundreds to thousands of microbial species living within the human body. These populations affect our health, fertility, and even our longevity. But how do they get there in the first place?

New collaborative work led by Carnegie’s William Ludington reveals crucial details about how the bacterial communities that comprise each of our individual gut microbiomes are acquired. These findings, published in the Proceedings of the National Academy of Sciences, have major implications for treatments such as fecal transplants and probiotic administration.

“There is a huge amount of variation in microbiome

Palm trees rise in front of the San Gabriel Mountains.
January 10, 2022

Washington, DC—California Governor Gavin Newsom on Monday announced $20 million in his 2023 fiscal year budget to support Carnegie’s new research facility in Pasadena. The proposed budget allocation still must clear the California State Senate and Assembly, which will begin to hold hearings in the coming weeks. It must be adopted by June 15. 

The new 135,000-square-foot, state-of-the-art campus will bring the institution’s life and environmental scientists together in a single location adjacent to Caltech—making a decisive investment in the global fight against climate change. The facility will house more than 200 new hires and relocated staff, who

Margaret McFall-Ngai
November 17, 2021

Washington, DC—Pioneering microbiome specialist Margaret McFall-Ngai has been named the inaugural director of Carnegie’s newly launched research division focused on life and environmental sciences, which will deploy an integrated, molecular-to-global approach to tackling the challenges of sustainability, resilience, and adaptation to a changing climate. McFall-Ngai will join the institution in January, 2022, from the University of Hawai‘i at Mānoa, where she is a professor at the Pacific Biosciences Research Center’s Kewalo Marine Laboratory and the center’s director emerita.

“Margaret’s exemplary research and groundbreaking vision are the

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Approximately half of the gene sequences of human and mouse genomes comes from so-called mobile elements—genes that jump around the genome. Much of this DNA is no longer capable of moving, but is likely “auditioning”  perhaps as a regulator of gene function or in homologous recombination, which is a type of genetic recombination where the basic structural units of DNA,  nucleotide sequences, are exchanged between two DNA molecules to  repair  breaks in the DNA  strands. Modern mammalian genomes also contain numerous intact movable elements, such as retrotransposon LINE-1, that use RNA intermediates to spread about the genome. 

Given

In mammals, most lipids, such as fatty acids and cholesterol, are absorbed into the body via the small intestine. The complexity of the cells and fluids that inhabit this organ make it very difficult to study in a laboratory setting. The goal of the Farber lab is to better understand the cell and molecular biology of lipids within digestive organs by exploiting the many unique attributes of the clear zebrafish larva  to visualize lipid uptake and processing in real time.  Given their utmost necessity for proper cellular function, it is not surprising that defects in lipid metabolism underlie a number of human diseases, including obesity, diabetes, and atherosclerosis.

The Gall laboratory studies all aspects of the cell nucleus, particularly the structure of chromosomes, the transcription and processing of RNA, and the role of bodies inside the cell nucleus, especially the Cajal body (CB) and the histone locus body (HLB).

Much of the work makes use of the giant oocyte of amphibians and the equally giant nucleus or germinal vesicle (GV) found in it. He is particularly  interested in how the structure of the nucleus is related to the synthesis and processing of RNA—specifically, what changes occur in the chromosomes and other nuclear components when RNA is synthesized, processed, and transported to the cytoplasm.

The Zheng lab studies cell division including the study of stem cells, genome organization, and lineage specification. They study the mechanism of genome organization in development, homeostasis—metabolic balance-- and aging; and the influence of cell morphogenesis, or cell shape and steructure,  on cell fate decisions. They use a wide range of tools and systems, including genetics in model organisms, cell culture, biochemistry, proteomics, and genomics.

 

Frederick Tan holds a unique position at Embryology in this era of high-throughput sequencing where determining DNA and RNA sequences has become one of the most powerful technologies in biology. DNA provides the basic code shared by all our cells to program our development. While there are about 30,000 human genes, 98% of DNA sequences are comprised of repetitive and regulatory sequences within and between genes. Measuring the specific set of DNA sequences that are transcribed into RNA helps reveal what and how our tissues are doing by showing which genes are active.

Modern sequencing platforms, such as the Illumina HiSeq 2000, generate only short, ordered sequences, usually 100

Integrity of hereditary material—the genome —is critical for species survival. Genomes need protection from agents that can cause mutations affecting DNA coding, regulatory functions, and duplication during cell division. DNA sequences called transposons, or jumping genes (discovered by Carnegie’s Barbara McClintock,) can multiply and randomly jump around the genome and cause mutations. About half of the sequence of the human and mouse genomes is derived from these mobile elements.  RNA interference (RNAi, codiscovered by Carnegie’s Andy Fire) and related processes are central to transposon control, particularly in egg and sperm precursor cells.  

The Donald Brown laboratory uses  amphibian metamorphosis to study complex developmental programs such as the development of vertebrate organs. The thyroid gland secretes thyroxine (TH), a hormone essential for the growth and development of all vertebrates including humans. To understand TH, director emeritus Donald Brown studies one of the most dramatic roles of the hormone, the control of amphibian metamorphosis—the process by which a tadpole turns into a frog. He studies the frog Xenopus laevis from South Africa.

 Events as different as the formation of limbs, the remodeling of organs, and the resorption of tadpole tissues such as the tail are all directed by TH

Brittany Belin joined the Department of Embryology staff in August 2020. Her Ph.D. research involved developing new tools for in vivo imaging of actin in cell nuclei. Actin is a major structural element in eukaryotic cells—cells with a nucleus and organelles —forming contractile polymers that drive muscle contraction, the migration of immune cells to  infection sites, and the movement of signals from one part of a cell to another. Using the tools developed in her Ph.D., Belin discovered a new role for actin in aiding the repair of DNA breaks in human cells caused by carcinogens, UV light, and other mutagens.

Belin changed course for her postdoctoral work, in