Palm trees rise in front of the San Gabriel Mountains.
Washington, DC—California Governor Gavin Newsom on Monday announced $20 million in his 2023 fiscal year budget to support Carnegie’s new research facility in Pasadena. The proposed budget...
Explore this Story
Margaret McFall-Ngai
Washington, DC—Pioneering microbiome specialist Margaret McFall-Ngai has been named the inaugural director of Carnegie’s newly launched research division focused on life and environmental...
Explore this Story
Artist's conception of this research project courtesy of Navid Marvi
Baltimore, MD—Carnegie’s Steven Farber was awarded nearly $500,000 over three years by The G. Harold & Leila Y. Mathers Foundation to identify the chemical components of cinnamon oil...
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Carnegie's William Ludington
Baltimore, MD—Carnegie William Ludington’s quest to understand the community ecology of our gut microbiome was this spring awarded nearly $1 million over three years from the National...
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Heart Reef in Australia's Great Barrier Reef, public domain.
Baltimore, MD— The CRISPR/Cas9 genome editing system can help scientists understand, and possibly improve, how corals respond to the environmental stresses of climate change. Work led by...
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Orange peyssonnelid algal crusts courtesy of Peter Edmunds.
Baltimore, MD—Human activity endangers coral health around the world. A new algal threat is taking advantage of coral’s already precarious situation in the Caribbean and making it even...
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Baltimore, MD— Recently published work from Carnegie’s Allan Spradling and Wanbao Niu revealed in unprecedented detail the genetic instructions immature egg cells go through step by step...
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Baltimore, MD— Recent work led by Carnegie’s Kamena Kostova revealed a new quality control system in the protein production assembly line with possible implications for understanding...
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The Spradling laboratory studies the biology of reproduction. By unknown means eggs reset the normally irreversible processes of differentiation and aging. The fruit fly Drosophila provides a favorable multicellular system for molecular genetic studies. The lab focuses on several aspects of egg...
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The Zheng lab studies cell division including the study of stem cells, genome organization, and lineage specification. They study the mechanism of genome organization in development, homeostasis—metabolic balance-- and aging; and the influence of cell morphogenesis, or cell shape and...
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The Fan laboratory studies the molecular mechanisms that govern mammalian development, using the mouse as a model. They use a combination of biochemical, molecular and genetic approaches to identify and characterize signaling molecules and pathways that control the development and maintenance of...
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The Ludington lab investigates complex ecological dynamics from microbial community interactions using the fruit fly  Drosophila melanogaster. The fruit fly gut carries numerous microbial species, which can be cultured in the lab. The goal is to understand the gut ecology...
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Frederick Tan holds a unique position at Embryology in this era of high-throughput sequencing where determining DNA and RNA sequences has become one of the most powerful technologies in biology. DNA provides the basic code shared by all our cells to program our development. While there are about 30...
Meet this Scientist
Yixian Zheng is Director of the Department of Embryology. Her lab has a long-standing interest in cell division. In recent years, their findings have broadened their research using animal models, to include the study of stem cells, genome organization, and lineage specification—how stem cells...
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The American Society for Cell Biology profiles Yixian Zheng and her recent papers on the elusive spindle matrix. "Zheng’s lab identifies new regulators in spindle assembly, all...
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Tasuku Honjo, a postdoctoral fellow in the Brown Lab at the Department of Embryology 1971-1973 shares the 2018 Nobel Prize in Physiology or Medicine.  
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Body organs such as the intestine and ovaries undergo structural changes in response to dietary nutrients that can have lasting impacts on metabolism, as well as cancer susceptibility, according to...
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Explore Carnegie Science

Palm trees rise in front of the San Gabriel Mountains.
January 10, 2022

Washington, DC—California Governor Gavin Newsom on Monday announced $20 million in his 2023 fiscal year budget to support Carnegie’s new research facility in Pasadena. The proposed budget allocation still must clear the California State Senate and Assembly, which will begin to hold hearings in the coming weeks. It must be adopted by June 15. 

The new 135,000-square-foot, state-of-the-art campus will bring the institution’s life and environmental scientists together in a single location adjacent to Caltech—making a decisive investment in the global fight against climate change. The facility will house more than 200 new hires and relocated staff, who

Margaret McFall-Ngai
November 17, 2021

Washington, DC—Pioneering microbiome specialist Margaret McFall-Ngai has been named the inaugural director of Carnegie’s newly launched research division focused on life and environmental sciences, which will deploy an integrated, molecular-to-global approach to tackling the challenges of sustainability, resilience, and adaptation to a changing climate. McFall-Ngai will join the institution in January, 2022, from the University of Hawai‘i at Mānoa, where she is a professor at the Pacific Biosciences Research Center’s Kewalo Marine Laboratory and the center’s director emerita.

“Margaret’s exemplary research and groundbreaking vision are the

Artist's conception of this research project courtesy of Navid Marvi
July 14, 2021

Baltimore, MD—Carnegie’s Steven Farber was awarded nearly $500,000 over three years by The G. Harold & Leila Y. Mathers Foundation to identify the chemical components of cinnamon oil that show effectiveness against cardiovascular disease-causing fats.

Fat molecules, or lipids, such as cholesterol and triglycerides are shuttled around the circulatory system by a protein called Apolipoprotein-B, together forming complexes of lipid and protein that are called lipoproteins but may be more commonly known as “bad cholesterol.” It can get embedded in the sides of blood vessels and harden, forming a dangerous buildup that makes it more difficult for the heart

Carnegie's William Ludington
July 14, 2021

Baltimore, MD—Carnegie William Ludington’s quest to understand the community ecology of our gut microbiome was this spring awarded nearly $1 million over three years from the National Science Foundation. He was also selected as one of 14 researchers to receive $55,000 from the Research Corporation for Science Advancement for its inaugural Scialog: Microbiome, Neurobiology, and Disease initiative.

“Since he arrived at Carnegie in 2018, Will has been aggressively pursuing breakthroughs in microbiome research—deploying a multitude of genetic, physiological, and mathematical approaches,” said Carnegie Embryology Director Yixian Zheng. “These two

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The Fan laboratory studies the molecular mechanisms that govern mammalian development, using the mouse as a model. They use a combination of biochemical, molecular and genetic approaches to identify and characterize signaling molecules and pathways that control the development and maintenance of the musculoskeletal and hypothalamic systems.

The musculoskeletal system provides the mechanical support for our posture and movement. How it arises during embryogenesis pertains to the basic problem of embryonic induction. How the components of this system are repaired after injury and maintained throughout life is of biological and clinical significance. They study how this system is

The Gall laboratory studies all aspects of the cell nucleus, particularly the structure of chromosomes, the transcription and processing of RNA, and the role of bodies inside the cell nucleus, especially the Cajal body (CB) and the histone locus body (HLB).

Much of the work makes use of the giant oocyte of amphibians and the equally giant nucleus or germinal vesicle (GV) found in it. He is particularly  interested in how the structure of the nucleus is related to the synthesis and processing of RNA—specifically, what changes occur in the chromosomes and other nuclear components when RNA is synthesized, processed, and transported to the cytoplasm.

Approximately half of the gene sequences of human and mouse genomes comes from so-called mobile elements—genes that jump around the genome. Much of this DNA is no longer capable of moving, but is likely “auditioning”  perhaps as a regulator of gene function or in homologous recombination, which is a type of genetic recombination where the basic structural units of DNA,  nucleotide sequences, are exchanged between two DNA molecules to  repair  breaks in the DNA  strands. Modern mammalian genomes also contain numerous intact movable elements, such as retrotransposon LINE-1, that use RNA intermediates to spread about the genome. 

Given

The Zheng lab studies cell division including the study of stem cells, genome organization, and lineage specification. They study the mechanism of genome organization in development, homeostasis—metabolic balance-- and aging; and the influence of cell morphogenesis, or cell shape and steructure,  on cell fate decisions. They use a wide range of tools and systems, including genetics in model organisms, cell culture, biochemistry, proteomics, and genomics.

 

The Donald Brown laboratory uses  amphibian metamorphosis to study complex developmental programs such as the development of vertebrate organs. The thyroid gland secretes thyroxine (TH), a hormone essential for the growth and development of all vertebrates including humans. To understand TH, director emeritus Donald Brown studies one of the most dramatic roles of the hormone, the control of amphibian metamorphosis—the process by which a tadpole turns into a frog. He studies the frog Xenopus laevis from South Africa.

 Events as different as the formation of limbs, the remodeling of organs, and the resorption of tadpole tissues such as the tail are all directed by TH

Integrity of hereditary material—the genome —is critical for species survival. Genomes need protection from agents that can cause mutations affecting DNA coding, regulatory functions, and duplication during cell division. DNA sequences called transposons, or jumping genes (discovered by Carnegie’s Barbara McClintock,) can multiply and randomly jump around the genome and cause mutations. About half of the sequence of the human and mouse genomes is derived from these mobile elements.  RNA interference (RNAi, codiscovered by Carnegie’s Andy Fire) and related processes are central to transposon control, particularly in egg and sperm precursor cells.  

The first step in gene expression is the formation of an RNA copy of its DNA. This step, called transcription, takes place in the cell nucleus. Transcription requires an enzyme called RNA polymerase to catalyze the synthesis of the RNA from the DNA template. This, in addition to other processing factors, is needed before messenger RNA (mRNA) can be exported to the cytoplasm, the area surrounding the nucleus.

Although the biochemical details of transcription and RNA processing are known, relatively little is understood about their cellular organization. Joseph G. Gall has been an intellectual leader and has made seminal breakthroughs in our understanding of chromosomes, nuclei and

Staff Associate Kamena Kostova joined the Department of Embryology in November 2018. She studies ribosomes, the factory-like structures inside cells that produce proteins. Scientists have known about ribosome structure, function, and biogenesis for some time. But, a major unanswered question is how cells monitor the integrity of the ribosome itself. Problems with ribosomes have been associated with diseases including neurodegeneration and cancer. The Kostova lab investigates the fundamental question of how cells respond when their ribosomes break down using mass spectrometry, functional genomics methods, and CRISPR genome editing.

Kostova received a B.S. in Biology from the