The Gall laboratory studies all aspects of the cell nucleus, particularly the structure of chromosomes, the transcription and processing of RNA, and the role of bodies inside the cell nucleus, especially the Cajal body (CB) and the histone locus body (HLB).
Much of the work makes use of the giant oocyte of amphibians and the equally giant nucleus or germinal vesicle (GV) found in it. He is particularly interested in how the structure of the nucleus is related to the synthesis and processing of RNA—specifically, what changes occur in the chromosomes and other nuclear components when RNA is synthesized, processed, and transported to the cytoplasm.