Baltimore, MD—A first-of-its-kind study on almost 20,000 K-12 underrepresented public school students shows that Project BioEYES, based at Carnegie’s Department of Embryology, is...
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Carnegie Science, Carnegie Institution, Carnegie Institution for Science
Baltimore, MD— New work led by Carnegie’s Steven Farber, with help from Yixian Zheng’s lab, sheds light on how form follows function for intestinal cells responding to high-fat...
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Carnegie Science, Carnegie Institution, Carnegie Institution for Science
Baltimore, MD---Athletes, the elderly and those with degenerative muscle disease would all benefit from accelerated muscle repair. When skeletal muscles, those connected to the bone, are injured,...
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Washington, D.C.—  Zehra Nizami has been a graduate student and postdoc in Joe Gall’s lab at the Department of Embryology. She is the fourth recipient of the Postdoctoral Innovation...
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Baltimore, MD--BioEYES, the K-12 science education program headquartered at  Carnegie's Department of Embryology, was recognized with four other organizations by the General Motors...
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Baltimore, MD— As we age, the function and regenerative abilities of skeletal muscles deteriorate, which means it is difficult for the elderly to recover from injury or surgery. New work from...
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Baltimore, MD—New work from Carnegie’s Allan Spradling and Lei Lei demonstrates that mammalian egg cells gain crucial cellular components at an early stage from their undifferentiated...
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Washington, D.C.—Matthew Sieber, a postdoctoral fellow at the Department of Embryology, has been honored for his extraordinary accomplishments, through a new program that recognizes exceptional...
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In mammals, most lipids, such as fatty acids and cholesterol, are absorbed into the body via the small intestine. The complexity of the cells and fluids that inhabit this organ make it very difficult to study in a laboratory setting. The goal of the Farber lab is to better understand the cell and...
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The Marnie Halpern laboratory studies how left-right differences arise in the developing brain and discovers the genes that control this asymmetry. Using the tiny zebrafish, Danio rerio, they explores how regional specializations occur within the neural tube, the embryonic tissue that develops into...
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The Gall laboratory studies all aspects of the cell nucleus, particularly the structure of chromosomes, the transcription and processing of RNA, and the role of bodies inside the cell nucleus, especially the Cajal body (CB) and the histone locus body (HLB). Much of the work makes use of the giant...
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The Ludington lab investigates complex ecological dynamics from microbial community interactions using the fruit fly  Drosophila melanogaster. The fruit fly gut carries numerous microbial species, which can be cultured in the lab. The goal is to understand the gut ecology...
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Staff Associate Kamena Kostova joined the Department of Embryology in November 2018. She studies ribosomes, the factory-like structures inside cells that produce proteins. Scientists have known about ribosome structure, function, and biogenesis for some time. But, a major unanswered question...
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Yixian Zheng is Director of the Department of Embryology. Her lab has a long-standing interest in cell division. In recent years, their findings have broadened their research using animal models, to include the study of stem cells, genome organization, and lineage specification—how stem cells...
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Martin Jonikas of Carnegie’s Department of Plant Biology and Zhao Zhang of the Department of Embryology, have been awarded the New Innovator and Early Independence Awards, respectively, from...
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Baltimore, MD—The newest member of the staff at the Carnegie Department of Embryology, Junior Investigator Zhao Zhang, received the prestigious Larry Sandler Memorial Award at the 56th Annual...
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The Pew Charitable Trust has awarded Carnegie’s Steve Farber and colleague John F. Rawls of Duke University a $200,000 grant to investigate how dietary nutrients, such as fats, alter the...
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Explore Carnegie Science

This image captures the bright blue light (chemiluminesc ence) emitted by the NanoLuc protein in LipoGlo zebrafish. It is is provided courtesy of James Thierer.
July 31, 2019

Baltimore, MD—A newly developed technique that shows artery clogging fat-and-protein complexes in live fish gave investigators from Carnegie, Johns Hopkins University, and the Mayo Clinic a glimpse of how to study heart disease in action. Their research, which is currently being used to find new drugs to fight cardiovascular disease, is now published in Nature Communications.

Fat molecules, also called lipids, such as cholesterol and triglycerides are shuttled around the circulatory system by a protein called Apolipoprotein-B, or ApoB for short. These complexes of lipid and protein are called lipoproteins but may be more commonly known as “bad cholesterol.”

One analogy for understanding the mathematical structure of the team's work is to think of it as foam being simplified into a single bubble by progressively merging adjacent bubbles.
July 2, 2019

Baltimore, MD—How do the communities of microbes living in our gastrointestinal systems affect our health? Carnegie’s Will Ludington was part of a team that helped answer this question.

For nearly a century, evolutionary biologists have probed how genes encode an individual’s chances for success—or fitness—in a specific environment.

In order to reveal a potential evolutionary trajectory biologists measure the interactions between genes to see which combinations are most fit.  An organism that is evolving should take the most fit path. This concept is called a fitness landscape, and various mathematical techniques have been developed to

June 17, 2019

Meredith Wilson, a postdoctoral associate in Steve Farber’s lab at the Department of Embryology, has been awarded Carnegie’s thirteenth Postdoctoral Innovation and Excellence Award. These prizes are given to postdocs for their exceptionally creative approaches to science, strong mentoring, and contributing to the sense of campus community. The nominations are made by the departments and are chosen by the Office of the President. The recipients receive a cash prize and are celebrated at an event at their departments.  

Wilson came to Carnegie in 2014 from the University of Pennsylvania with a background in cell biology investigating how motor proteins position

Illustration of a thymus in a human chest courtesy of Navid Marvi.
May 29, 2019

Washington, DC—Aging-related inflammation can drive the decline of a critical structural protein called lamin-B1, which contributes to diminished immune function in the thymus, according to research from Carnegie’s Sibiao Yue, Xiaobin Zheng, and Yixian Zheng published in Aging Cell.

Each of our cells is undergirded by a protein-based cellular skeleton. And each of our tissues is likewise supported by a protein matrix holding the cells that comprise it together. These protein scaffolds or structures are necessary for organs and tissues to be constructed during development.

“Since organ building and maintenance require this protein-based structural support

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The Marnie Halpern laboratory studies how left-right differences arise in the developing brain and discovers the genes that control this asymmetry. Using the tiny zebrafish, Danio rerio, they explores how regional specializations occur within the neural tube, the embryonic tissue that develops into the brain and spinal cord.

The zebrafish is ideal for these studies because its basic body plan is set within 24 hours of fertilization. By day five, young larvae are able to feed and swim, and within three months they are ready to reproduce. They are also prolific breeders. Most importantly the embryos are transparent, allowing scientists to watch the nervous system develop and to

The Spradling laboratory studies the biology of reproduction. By unknown means eggs reset the normally irreversible processes of differentiation and aging. The fruit fly Drosophila provides a favorable multicellular system for molecular genetic studies. The lab focuses on several aspects of egg development, called oogenesis, which promises to provide insight into the rejuvenation of the nucleus and surrounding cytoplasm. By studying ovarian stem cells, they are learning how cells maintain an undifferentiated state and how cell production is regulated by microenvironments known as niches. They are  also re-investigating the role of steroid and prostaglandin hormones in controlling

The Gall laboratory studies all aspects of the cell nucleus, particularly the structure of chromosomes, the transcription and processing of RNA, and the role of bodies inside the cell nucleus, especially the Cajal body (CB) and the histone locus body (HLB).

Much of the work makes use of the giant oocyte of amphibians and the equally giant nucleus or germinal vesicle (GV) found in it. He is particularly  interested in how the structure of the nucleus is related to the synthesis and processing of RNA—specifically, what changes occur in the chromosomes and other nuclear components when RNA is synthesized, processed, and transported to the cytoplasm.

Approximately half of the gene sequences of human and mouse genomes comes from so-called mobile elements—genes that jump around the genome. Much of this DNA is no longer capable of moving, but is likely “auditioning”  perhaps as a regulator of gene function or in homologous recombination, which is a type of genetic recombination where the basic structural units of DNA,  nucleotide sequences, are exchanged between two DNA molecules to  repair  breaks in the DNA  strands. Modern mammalian genomes also contain numerous intact movable elements, such as retrotransposon LINE-1, that use RNA intermediates to spread about the genome. 

Given

The mouse is a traditional model organism for understanding physiological processes in humans. Chen-Ming Fan uses the mouse to study the underlying mechanisms involved in human development and genetic diseases. He concentrates on identifying and understanding the signals that direct the musculoskeletal system to develop in the mammalian embryo. Skin, muscle, cartilage, and bone are all derived from a group of progenitor structures called somites. Various growth factors—molecules that stimulate the growth of cells—in the surrounding tissues work in concert to signal each somitic cell to differentiate into a specific tissue type.

The lab has identified various growth

The first step in gene expression is the formation of an RNA copy of its DNA. This step, called transcription, takes place in the cell nucleus. Transcription requires an enzyme called RNA polymerase to catalyze the synthesis of the RNA from the DNA template. This, in addition to other processing factors, is needed before messenger RNA (mRNA) can be exported to the cytoplasm, the area surrounding the nucleus.

Although the biochemical details of transcription and RNA processing are known, relatively little is understood about their cellular organization. Joseph G. Gall has been an intellectual leader and has made seminal breakthroughs in our understanding of chromosomes, nuclei and

Yixian Zheng is Director of the Department of Embryology. Her lab has a long-standing interest in cell division. In recent years, their findings have broadened their research using animal models, to include the study of stem cells, genome organization, and lineage specification—how stem cells differentiate into their final cell forms. They use a wide range of tools, including genetics in different model organisms, cell culture, biochemistry, proteomics, and genomics.

Cell division is essential for all organisms to grow and live. During a specific time in a cell’s cycle the elongated apparatus consisting of string-like micro-tubules called the spindle is assembled to

Integrity of hereditary material—the genome —is critical for species survival. Genomes need protection from agents that can cause mutations affecting DNA coding, regulatory functions, and duplication during cell division. DNA sequences called transposons, or jumping genes (discovered by Carnegie’s Barbara McClintock,) can multiply and randomly jump around the genome and cause mutations. About half of the sequence of the human and mouse genomes is derived from these mobile elements.  RNA interference (RNAi, codiscovered by Carnegie’s Andy Fire) and related processes are central to transposon control, particularly in egg and sperm precursor cells.