Baltimore, MD— As we age, the function and regenerative abilities of skeletal muscles deteriorate, which means it is difficult for the elderly to recover from injury or surgery. New work from...
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Baltimore, MD—New work from Carnegie’s Allan Spradling and Lei Lei demonstrates that mammalian egg cells gain crucial cellular components at an early stage from their undifferentiated...
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Washington, D.C.—Matthew Sieber, a postdoctoral fellow at the Department of Embryology, has been honored for his extraordinary accomplishments, through a new program that recognizes exceptional...
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Baltimore, MD— Reproduction is highly dependent on diet and the ability to use nutrients to grow and generate energy. This is clearly seen in women, who must provide all the nutritional...
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San Diego, CA— Ghosts are not your typical cell biology research subjects. But scientists at the Carnegie Institution for Science and the National Institute of Child Health and Human...
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The American Society for Cell Biology profiles Yixian Zheng and her recent papers on the elusive spindle matrix. "Zheng’s lab identifies new regulators in spindle assembly, all...
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Two researchers, Martin Jonikas of Carnegie’s Department of Plant Biology and Zhao Zhang of the Department of Embryology, have been awarded the New Innovator and Early Independence Awards,...
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Baltimore, MD— Every high school biology class learns about the tiny cells that comprise our bodies, as well as about many of the diverse actions that they perform. One of these actions is...
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Approximately half of the gene sequences of human and mouse genomes comes from so-called mobile elements—genes that jump around the genome. Much of this DNA is no longer capable of moving, but is likely “auditioning”  perhaps as a regulator of gene function or in homologous...
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The Gall laboratory studies all aspects of the cell nucleus, particularly the structure of chromosomes, the transcription and processing of RNA, and the role of bodies inside the cell nucleus, especially the Cajal body (CB) and the histone locus body (HLB). Much of the work makes use of the giant...
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The Fan laboratory studies the molecular mechanisms that govern mammalian development, using the mouse as a model. They use a combination of biochemical, molecular and genetic approaches to identify and characterize signaling molecules and pathways that control the development and maintenance of...
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Phillip Cleves’ Ph.D. research was on determining the genetic changes that drive morphological evolution. He used the emerging model organism, the stickleback fish, to map genetic changes that control skeletal evolution. Using new genetic mapping and reverse genetic tools developed during his...
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The mouse is a traditional model organism for understanding physiological processes in humans. Chen-Ming Fan uses the mouse to study the underlying mechanisms involved in human development and genetic diseases. He concentrates on identifying and understanding the signals that direct the...
Meet this Scientist
Allan Spradling is a Howard Hughes Medical Institute Investigator and director emeritus of the Department of Embryology. His laboratory studies the biology of reproduction particularly egg cells, which are able to reset the normally irreversible processes of differentiation and aging that govern...
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Baltimore, MD— As we age, the function and regenerative abilities of skeletal muscles deteriorate, which means it is difficult for the elderly to recover from injury or surgery. New work from...
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Body organs such as the intestine and ovaries undergo structural changes in response to dietary nutrients that can have lasting impacts on metabolism, as well as cancer susceptibility, according to...
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Baltimore, MD--The General Motors Corporation is presenting a $5,000.00 award to Carnegie’s BioEYES K-12 educational program on September 11, 2014, to deliver a two-week environmental curriculum,...
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Explore Carnegie Science

Artist's conception by Navid Marvi
February 9, 2022

Baltimore, MD— The gut microbiome is an ecosystem of hundreds to thousands of microbial species living within the human body. These populations affect our health, fertility, and even our longevity. But how do they get there in the first place?

New collaborative work led by Carnegie’s William Ludington reveals crucial details about how the bacterial communities that comprise each of our individual gut microbiomes are acquired. These findings, published in the Proceedings of the National Academy of Sciences, have major implications for treatments such as fecal transplants and probiotic administration.

“There is a huge amount of variation in microbiome

Palm trees rise in front of the San Gabriel Mountains.
January 10, 2022

Washington, DC—California Governor Gavin Newsom on Monday announced $20 million in his 2023 fiscal year budget to support Carnegie’s new research facility in Pasadena. The proposed budget allocation still must clear the California State Senate and Assembly, which will begin to hold hearings in the coming weeks. It must be adopted by June 15. 

The new 135,000-square-foot, state-of-the-art campus will bring the institution’s life and environmental scientists together in a single location adjacent to Caltech—making a decisive investment in the global fight against climate change. The facility will house more than 200 new hires and relocated staff, who

Margaret McFall-Ngai
November 17, 2021

Washington, DC—Pioneering microbiome specialist Margaret McFall-Ngai has been named the inaugural director of Carnegie’s newly launched research division focused on life and environmental sciences, which will deploy an integrated, molecular-to-global approach to tackling the challenges of sustainability, resilience, and adaptation to a changing climate. McFall-Ngai will join the institution in January, 2022, from the University of Hawai‘i at Mānoa, where she is a professor at the Pacific Biosciences Research Center’s Kewalo Marine Laboratory and the center’s director emerita.

“Margaret’s exemplary research and groundbreaking vision are the

Artist's conception of this research project courtesy of Navid Marvi
July 14, 2021

Baltimore, MD—Carnegie’s Steven Farber was awarded nearly $500,000 over three years by The G. Harold & Leila Y. Mathers Foundation to identify the chemical components of cinnamon oil that show effectiveness against cardiovascular disease-causing fats.

Fat molecules, or lipids, such as cholesterol and triglycerides are shuttled around the circulatory system by a protein called Apolipoprotein-B, together forming complexes of lipid and protein that are called lipoproteins but may be more commonly known as “bad cholesterol.” It can get embedded in the sides of blood vessels and harden, forming a dangerous buildup that makes it more difficult for the heart

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Approximately half of the gene sequences of human and mouse genomes comes from so-called mobile elements—genes that jump around the genome. Much of this DNA is no longer capable of moving, but is likely “auditioning”  perhaps as a regulator of gene function or in homologous recombination, which is a type of genetic recombination where the basic structural units of DNA,  nucleotide sequences, are exchanged between two DNA molecules to  repair  breaks in the DNA  strands. Modern mammalian genomes also contain numerous intact movable elements, such as retrotransposon LINE-1, that use RNA intermediates to spread about the genome. 

Given

The Zheng lab studies cell division including the study of stem cells, genome organization, and lineage specification. They study the mechanism of genome organization in development, homeostasis—metabolic balance-- and aging; and the influence of cell morphogenesis, or cell shape and steructure,  on cell fate decisions. They use a wide range of tools and systems, including genetics in model organisms, cell culture, biochemistry, proteomics, and genomics.

 

The Gall laboratory studies all aspects of the cell nucleus, particularly the structure of chromosomes, the transcription and processing of RNA, and the role of bodies inside the cell nucleus, especially the Cajal body (CB) and the histone locus body (HLB).

Much of the work makes use of the giant oocyte of amphibians and the equally giant nucleus or germinal vesicle (GV) found in it. He is particularly  interested in how the structure of the nucleus is related to the synthesis and processing of RNA—specifically, what changes occur in the chromosomes and other nuclear components when RNA is synthesized, processed, and transported to the cytoplasm.

The Fan laboratory studies the molecular mechanisms that govern mammalian development, using the mouse as a model. They use a combination of biochemical, molecular and genetic approaches to identify and characterize signaling molecules and pathways that control the development and maintenance of the musculoskeletal and hypothalamic systems.

The musculoskeletal system provides the mechanical support for our posture and movement. How it arises during embryogenesis pertains to the basic problem of embryonic induction. How the components of this system are repaired after injury and maintained throughout life is of biological and clinical significance. They study how this system is

The Donald Brown laboratory uses  amphibian metamorphosis to study complex developmental programs such as the development of vertebrate organs. The thyroid gland secretes thyroxine (TH), a hormone essential for the growth and development of all vertebrates including humans. To understand TH, director emeritus Donald Brown studies one of the most dramatic roles of the hormone, the control of amphibian metamorphosis—the process by which a tadpole turns into a frog. He studies the frog Xenopus laevis from South Africa.

 Events as different as the formation of limbs, the remodeling of organs, and the resorption of tadpole tissues such as the tail are all directed by TH

Staff Associate Kamena Kostova joined the Department of Embryology in November 2018. She studies ribosomes, the factory-like structures inside cells that produce proteins. Scientists have known about ribosome structure, function, and biogenesis for some time. But, a major unanswered question is how cells monitor the integrity of the ribosome itself. Problems with ribosomes have been associated with diseases including neurodegeneration and cancer. The Kostova lab investigates the fundamental question of how cells respond when their ribosomes break down using mass spectrometry, functional genomics methods, and CRISPR genome editing.

Kostova received a B.S. in Biology from the

The Ludington lab investigates complex ecological dynamics from microbial community interactions using the fruit fly  Drosophila melanogaster. The fruit fly gut carries numerous microbial species, which can be cultured in the lab. The goal is to understand the gut ecology and how it relates to host health, among other questions, by taking advantage of the fast time-scale and ease of studying the fruit fly in controlled experiments. 

Phillip Cleves’ Ph.D. research was on determining the genetic changes that drive morphological evolution. He used the emerging model organism, the stickleback fish, to map genetic changes that control skeletal evolution. Using new genetic mapping and reverse genetic tools developed during his Ph.D., Cleves identified regulatory changes in a protein called bone morphogenetic protein 6 that were responsible for an evolved increase in tooth number in stickleback. This work illustrated how molecular changes can generate morphological novelty in vertebrates.

Cleves returned to his passion for coral research in his postdoctoral work in John Pringles’ lab at Stanford