AudioBaltimore, MD—Proper tissue function and regeneration is supported by stem cells, which reside in so-called niches. New work from...
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Baltimore, MD—Mammalian females ovulate periodically over their reproductive lifetimes, placing significant demands on their ovaries for egg production. Whether mammals generate new eggs in adulthood...
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Baltimore, MD— Eggs take a long time to produce in the ovary, and thus are one of a body’s precious resources. It has been theorized that the body has mechanisms to help the ovary ensure that...
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Baltimore, MD— The ability of embryonic stem cells to differentiate into different types of cells with different functions is regulated and maintained by a complex series of chemical interactions,...
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Washington, D.C.—The Carnegie Institution for Science and the University of Massachusetts Medical School (UMMS) have been granted United States Patent 8,283,329, entitled, “Genetic inhibition of...
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Baltimore, MD —You may think you have dinner all to yourself, but you’re actually sharing it with a vast community of microbes waiting within your digestive tract. A new study from a team including...
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Baltimore, MD—Director Emeritus Donald Brown, of Carnegie’s Department of Embryology, receives the prestigious 2012 Lasker-Koshland Special Achievement Award in Medical Science “For exceptional...
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Baltimore, MD — The study of muscular system protein myostatin has been of great interest to researchers as a potential therapeutic target for people with muscular disorders. Although much is known...
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The Spradling laboratory studies the biology of reproduction. By unknown means eggs reset the normally irreversible processes of differentiation and aging. The fruit fly Drosophila provides a favorable multicellular system for molecular genetic studies. The lab focuses on several aspects of egg...
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Stem cells make headline news as potential treatments for a variety of diseases. But undertstanding the nuts and bolts of how they develop from an undifferentiated cell  that gives rise to cells that are specialized such as organs, or bones, and the nervous system, is not well understood.  The...
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The thyroid gland secretes thyroxine (TH), a hormone essential for the growth and development of all vertebrates including humans. To understand TH action, the Donald Brown lab studies one of the most dramatic roles of the hormone, the control of amphibian metamorphosis—the process by which a...
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The mouse is a traditional model organism for understanding physiological processes in humans. Chen-Ming Fan uses the mouse to study the underlying mechanisms involved in human development and genetic diseases. He concentrates on identifying and understanding the signals that direct the...
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The Donald Brown laboratory uses  amphibian metamorphosis to study complex developmental programs such as the development of vertebrate organs. The thyroid gland secretes thyroxine (TH), a hormone essential for the growth and development of all vertebrates including humans. To understand TH,...
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There is a lot of folklore about left-brain, right-brain differences—the right side of the brain is supposed to be the creative side, while the left is the logical half. But it’s much more complicated than that. Marnie Halpern studies how left-right differences arise in the developing brain and...
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Explore Carnegie Science

May 7, 2018

Baltimore, MD—Allan C. Spradling, Director Emeritus of Carnegie’s Department of Embryology, has been awarded the 23rd March of Dimes and Richard B. Johnson, Jr., MD Prize in Developmental Biology as “an outstanding scientist who has profoundly advanced the science that underlies our understanding of prenatal development and pregnancy.”

Department director and Carnegie co-interim president Yixian Zheng remarked, “Allan is a legend in developmental biology. We are all delighted by this well- deserved recognition of Allan’s groundbreaking research.”

Spradling’s decades of scientific accomplishments cover a broad spectrum of advancements. Since the early 20th century, the fruit

Carnegie Science, Carnegie Institution, Carnegie Institution for Science, Neta Schwartz
November 27, 2017

Washington, DC—Not too long ago, biologists would induce mutations in an entire genome, isolate an organism that displayed a resulting disease or abnormality that they wanted to study, and then work backward to determine which gene was responsible for the defect.  This process often took years to yield definitive results.

Now, thanks to the CRISPR/Cas9 genome-editing tool, biologists can target specific genes for mutation and then see how this induced mutation manifests in an organism—tackling the problem from the other direction. But they are finding that the expected physical changes don’t always occur.


New work from Carnegie’s Steven Farber and Jennifer

Carnegie Science, Carnegie Institution, Carnegie Institution for Science,
July 13, 2017

Baltimore, MD— The brain is the body’s mission control center, sending messages to the other organs about how to respond to various external and internal stimuli. Located in the forebrain, the habenular region is one such message-conducting system. Two new papers from Carnegie scientists explain how the habenulae develop and their unsuspected role in recovering from fear.

Found in all vertebrates, the bilaterally paired habenulae regulate the transmission of dopamine and serotonin, two important chemicals related to motor control, mood, and learning.

Previous research has shown that the habenular system is involved in modulating sleep cycles, anxiety, and pain and reward

Carnegie Science, Carnegie Institution, Carnegie Institution for Science,
July 6, 2017

Washington, D.C.--Yixian Zheng has been selected to direct Carnegie’s Department of Embryology in Baltimore, Maryland. She has been Acting Director since February 1st of 2016.

Carnegie president Matthew Scott remarked, “Yixian has been an exceptional leader of the department as Acting Director. We are extremely pleased that she took on this job permanently.  Her fascinating science, independent thinking, vision, extraordinary management skills, and perfect temperament are a tremendous asset to Carnegie Science.”

The Zheng lab has a long-standing interest in cell division and the cytoskeleton—the lattice arrangement of rods and fibers and motors that gives shape to cells and

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The Fan laboratory studies the molecular mechanisms that govern mammalian development, using the mouse as a model. They use a combination of biochemical, molecular and genetic approaches to identify and characterize signaling molecules and pathways that control the development and maintenance of the musculoskeletal and hypothalamic systems.

The musculoskeletal system provides the mechanical support for our posture and movement. How it arises during embryogenesis pertains to the basic problem of embryonic induction. How the components of this system are repaired after injury and maintained throughout life is of biological and clinical significance. They study how this system is

The Gall laboratory studies all aspects of the cell nucleus, particularly the structure of chromosomes, the transcription and processing of RNA, and the role of bodies inside the cell nucleus, especially the Cajal body (CB) and the histone locus body (HLB).

Much of the work makes use of the giant oocyte of amphibians and the equally giant nucleus or germinal vesicle (GV) found in it. He is particularly  interested in how the structure of the nucleus is related to the synthesis and processing of RNA—specifically, what changes occur in the chromosomes and other nuclear components when RNA is synthesized, processed, and transported to the cytoplasm.

Approximately half of the gene sequences of human and mouse genomes comes from so-called mobile elements—genes that jump around the genome. Much of this DNA is no longer capable of moving, but is likely “auditioning”  perhaps as a regulator of gene function or in homologous recombination, which is a type of genetic recombination where the basic structural units of DNA,  nucleotide sequences, are exchanged between two DNA molecules to  repair  breaks in the DNA  strands. Modern mammalian genomes also contain numerous intact movable elements, such as retrotransposon LINE-1, that use RNA intermediates to spread about the genome. 

Given the crucial role of the precursor cells to egg

In mammals, most lipids, such as fatty acids and cholesterol, are absorbed into the body via the small intestine. The complexity of the cells and fluids that inhabit this organ make it very difficult to study in a laboratory setting. The goal of the Farber lab is to better understand the cell and molecular biology of lipids within digestive organs by exploiting the many unique attributes of the clear zebrafish larva  to visualize lipid uptake and processing in real time.  Given their utmost necessity for proper cellular function, it is not surprising that defects in lipid metabolism underlie a number of human diseases, including obesity, diabetes, and atherosclerosis.

The Farber

Integrity of hereditary material—the genome —is critical for species survival. Genomes need protection from agents that can cause mutations affecting DNA coding, regulatory functions, and duplication during cell division. DNA sequences called transposons, or jumping genes (discovered by Carnegie’s Barbara McClintock,) can multiply and randomly jump around the genome and cause mutations. About half of the sequence of the human and mouse genomes is derived from these mobile elements.  RNA interference (RNAi, codiscovered by Carnegie’s Andy Fire) and related processes are central to transposon control, particularly in egg and sperm precursor cells.  

The Bortvin lab, with colleagues

Junior investigator Zhao Zhang joined Carnegie in November 2014. He studies how elements with the ability to “jump” around the genome, called transposons, are controlled in egg, sperm, and other somatic tissues in order to understand how transposons contribute to genomic instability and to mutations that lead to inherited disease and cancer. He particularly focuses on transposon control and its consequences in gonads compared to other tissues and has discovered novel connections to how gene transcripts are processed in the nucleus.To accomplish this work, Zhang frequently develops new tools and techniques, a characteristic of many outstanding Carnegie researchers. He recently received

Allan Spradling is a Howard Hughes Medical Institute Investigator and director of the Department of Embryology. His laboratory studies the biology of reproduction particularly egg cells, which are able to reset the normally irreversible processes of differentiation and aging that govern all somatic cells—those that turn into non-reproductive tissues. Spradling uses the fruit fly Drosophila because the genes and processes studied are likely to be similar to those in other organisms including humans. In the 1980s he and his colleague, Gerald Rubin, showed how jumping genes could be used to identify and manipulate fruit fly genes. Their innovative technique helped establish Drosophila as

The first step in gene expression is the formation of an RNA copy of its DNA. This step, called transcription, takes place in the cell nucleus. Transcription requires an enzyme called RNA polymerase to catalyze the synthesis of the RNA from the DNA template. This, in addition to other processing factors, is needed before messenger RNA (mRNA) can be exported to the cytoplasm, the area surrounding the nucleus.

Although the biochemical details of transcription and RNA processing are known, relatively little is understood about their cellular organization. Joseph G. Gall has been an intellectual leader and has made seminal breakthroughs in our understanding of chromosomes, nuclei and