Baltimore, MD—Allan C. Spradling, Director Emeritus of Carnegie’s Department of Embryology, has been awarded the 23rd March of Dimes and Richard B. Johnson, Jr., MD Prize in...
Explore this Story
Carnegie Science, Carnegie Institution, Carnegie Institution for Science, Neta Schwartz
Washington, DC—Not too long ago, biologists would induce mutations in an entire genome, isolate an organism that displayed a resulting disease or abnormality that they wanted to study, and then...
Explore this Story
Carnegie Science, Carnegie Institution, Carnegie Institution for Science,
Baltimore, MD— The brain is the body’s mission control center, sending messages to the other organs about how to respond to various external and internal stimuli. Located in the forebrain...
Explore this Story
Carnegie Science, Carnegie Institution, Carnegie Institution for Science,
Washington, D.C.--Yixian Zheng has been selected to direct Carnegie’s Department of Embryology in Baltimore, Maryland. She has been Acting Director since February 1st of 2016. Carnegie...
Explore this Story
Washington, D.C.—BioEYES was accepted to participate in a National Science Foundation (NSF) video competition on May 15-22, 2017. BioEYES supporters are encouraged to go to the competition...
Explore this Story
On Tuesday night, George Church told us that a fascination with animatronic Abraham Lincoln at the 1964 World’s Fair partially inspired him to become a scientist. This seems fitting, somehow,...
Explore this Story
Carnegie Science, Carnegie Institution, Carnegie Institution for Science
Baltimore, MD—Studying how our bodies metabolize lipids such as fatty acids, triglycerides, and cholesterol can teach us about cardiovascular disease, diabetes, and other health problems, as...
Explore this Story
People often call dogs “man’s best friend.” But after Elaine Ostrander’s presentation at our Washington, DC, headquarters Thursday, we think that moniker should probably be...
Explore this Story

Pages

The Fan laboratory studies the molecular mechanisms that govern mammalian development, using the mouse as a model. They use a combination of biochemical, molecular and genetic approaches to identify and characterize signaling molecules and pathways that control the development and maintenance of...
Explore this Project
The Gall laboratory studies all aspects of the cell nucleus, particularly the structure of chromosomes, the transcription and processing of RNA, and the role of bodies inside the cell nucleus, especially the Cajal body (CB) and the histone locus body (HLB). Much of the work makes use of the giant...
Explore this Project
The Zheng lab studies cell division including the study of stem cells, genome organization, and lineage specification. They study the mechanism of genome organization in development, homeostasis—metabolic balance-- and aging; and the influence of cell morphogenesis, or cell shape and...
Explore this Project
Staff Associate Kamena Kostova joined the Department of Embryology in November 2018. She studies ribosomes, the factory-like structures inside cells that produce proteins. Scientists have known about ribosome structure, function, and biogenesis for some time. But, a major unanswered question...
Meet this Scientist
The Donald Brown laboratory uses  amphibian metamorphosis to study complex developmental programs such as the development of vertebrate organs. The thyroid gland secretes thyroxine (TH), a hormone essential for the growth and development of all vertebrates including humans. To understand TH,...
Meet this Scientist
The Ludington lab investigates complex ecological dynamics from microbial community interactions using the fruit fly  Drosophila melanogaster. The fruit fly gut carries numerous microbial species, which can be cultured in the lab. The goal is to understand the gut ecology...
Meet this Scientist
You May Also Like...
Washington, D.C.—BioEYES was accepted to participate in a National Science Foundation (NSF) video competition on May 15-22, 2017. BioEYES supporters are encouraged to go to the competition website at...
Explore this Story
Tasuku Honjo, a postdoctoral fellow in the Brown Lab at the Department of Embryology 1971-1973 shares the 2018 Nobel Prize in Physiology or Medicine.  
Explore this Story
Baltimore, MD— A woman’s supply of eggs is a precious commodity because only a few hundred mature eggs can be produced throughout her lifetime and each must be as free as possible from genetic damage...
Explore this Story

Explore Carnegie Science

Artist's conception of this research project courtesy of Navid Marvi
July 14, 2021

Baltimore, MD—Carnegie’s Steven Farber was awarded nearly $500,000 over three years by The G. Harold & Leila Y. Mathers Foundation to identify the chemical components of cinnamon oil that show effectiveness against cardiovascular disease-causing fats.

Fat molecules, or lipids, such as cholesterol and triglycerides are shuttled around the circulatory system by a protein called Apolipoprotein-B, together forming complexes of lipid and protein that are called lipoproteins but may be more commonly known as “bad cholesterol.” It can get embedded in the sides of blood vessels and harden, forming a dangerous buildup that makes it more difficult for the heart

Carnegie's William Ludington
July 14, 2021

Baltimore, MD—Carnegie William Ludington’s quest to understand the community ecology of our gut microbiome was this spring awarded nearly $1 million over three years from the National Science Foundation. He was also selected as one of 14 researchers to receive $55,000 from the Research Corporation for Science Advancement for its inaugural Scialog: Microbiome, Neurobiology, and Disease initiative.

“Since he arrived at Carnegie in 2018, Will has been aggressively pursuing breakthroughs in microbiome research—deploying a multitude of genetic, physiological, and mathematical approaches,” said Carnegie Embryology Director Yixian Zheng. “These two

Heart Reef in Australia's Great Barrier Reef, public domain.
December 21, 2020

Baltimore, MD— The CRISPR/Cas9 genome editing system can help scientists understand, and possibly improve, how corals respond to the environmental stresses of climate change. Work led by Phillip Cleves—who joined Carnegie’s Department of Embryology this fall—details how the revolutionary, Nobel Prize-winning technology can be deployed to guide conservation efforts for fragile reef ecosystems.

Cleves’ research team’s findings were recently published in two papers in the Proceedings of the National Academy of Sciences.

Corals are marine invertebrates that build extensive calcium carbonate skeletons from which reefs are constructed. But this

Orange peyssonnelid algal crusts courtesy of Peter Edmunds.
November 30, 2020

Baltimore, MD—Human activity endangers coral health around the world. A new algal threat is taking advantage of coral’s already precarious situation in the Caribbean and making it even harder for reef ecosystems to grow.

Just-published research in Scientific Reports details how an aggressive, golden-brown, crust-like alga is rapidly overgrowing shallow reefs, taking the place of coral that was damaged by extreme storms and exacerbating the damage caused by ocean acidification, disease, pollution, and bleaching.

For the past four years, the University of Oxford’s Bryan Wilson, Carnegie’s Chen‑Ming Fan, and California State University Northridge’

No content in this section.

In mammals, most lipids, such as fatty acids and cholesterol, are absorbed into the body via the small intestine. The complexity of the cells and fluids that inhabit this organ make it very difficult to study in a laboratory setting. The goal of the Farber lab is to better understand the cell and molecular biology of lipids within digestive organs by exploiting the many unique attributes of the clear zebrafish larva  to visualize lipid uptake and processing in real time.  Given their utmost necessity for proper cellular function, it is not surprising that defects in lipid metabolism underlie a number of human diseases, including obesity, diabetes, and atherosclerosis.

The Zheng lab studies cell division including the study of stem cells, genome organization, and lineage specification. They study the mechanism of genome organization in development, homeostasis—metabolic balance-- and aging; and the influence of cell morphogenesis, or cell shape and steructure,  on cell fate decisions. They use a wide range of tools and systems, including genetics in model organisms, cell culture, biochemistry, proteomics, and genomics.

 

The Fan laboratory studies the molecular mechanisms that govern mammalian development, using the mouse as a model. They use a combination of biochemical, molecular and genetic approaches to identify and characterize signaling molecules and pathways that control the development and maintenance of the musculoskeletal and hypothalamic systems.

The musculoskeletal system provides the mechanical support for our posture and movement. How it arises during embryogenesis pertains to the basic problem of embryonic induction. How the components of this system are repaired after injury and maintained throughout life is of biological and clinical significance. They study how this system is

The Spradling laboratory studies the biology of reproduction. By unknown means eggs reset the normally irreversible processes of differentiation and aging. The fruit fly Drosophila provides a favorable multicellular system for molecular genetic studies. The lab focuses on several aspects of egg development, called oogenesis, which promises to provide insight into the rejuvenation of the nucleus and surrounding cytoplasm. By studying ovarian stem cells, they are learning how cells maintain an undifferentiated state and how cell production is regulated by microenvironments known as niches. They are  also re-investigating the role of steroid and prostaglandin hormones in controlling

Integrity of hereditary material—the genome —is critical for species survival. Genomes need protection from agents that can cause mutations affecting DNA coding, regulatory functions, and duplication during cell division. DNA sequences called transposons, or jumping genes (discovered by Carnegie’s Barbara McClintock,) can multiply and randomly jump around the genome and cause mutations. About half of the sequence of the human and mouse genomes is derived from these mobile elements.  RNA interference (RNAi, codiscovered by Carnegie’s Andy Fire) and related processes are central to transposon control, particularly in egg and sperm precursor cells.  

Allan Spradling is a Howard Hughes Medical Institute Investigator and director emeritus of the Department of Embryology. His laboratory studies the biology of reproduction particularly egg cells, which are able to reset the normally irreversible processes of differentiation and aging that govern all somatic cells—those that turn into non-reproductive tissues. Spradling uses the fruit fly Drosophila because the genes and processes studied are likely to be similar to those in other organisms including humans. In the 1980s he and his colleague, Gerald Rubin, showed how jumping genes could be used to identify and manipulate fruit fly genes. Their innovative technique helped establish

Frederick Tan holds a unique position at Embryology in this era of high-throughput sequencing where determining DNA and RNA sequences has become one of the most powerful technologies in biology. DNA provides the basic code shared by all our cells to program our development. While there are about 30,000 human genes, 98% of DNA sequences are comprised of repetitive and regulatory sequences within and between genes. Measuring the specific set of DNA sequences that are transcribed into RNA helps reveal what and how our tissues are doing by showing which genes are active.

Modern sequencing platforms, such as the Illumina HiSeq 2000, generate only short, ordered sequences, usually 100

Phillip Cleves’ Ph.D. research was on determining the genetic changes that drive morphological evolution. He used the emerging model organism, the stickleback fish, to map genetic changes that control skeletal evolution. Using new genetic mapping and reverse genetic tools developed during his Ph.D., Cleves identified regulatory changes in a protein called bone morphogenetic protein 6 that were responsible for an evolved increase in tooth number in stickleback. This work illustrated how molecular changes can generate morphological novelty in vertebrates.

Cleves returned to his passion for coral research in his postdoctoral work in John Pringles’ lab at Stanford