Artist's conception of this research project courtesy of Navid Marvi
Baltimore, MD—Carnegie’s Steven Farber was awarded nearly $500,000 over three years by The G. Harold & Leila Y. Mathers Foundation to identify the chemical components of cinnamon oil...
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Carnegie's William Ludington
Baltimore, MD—Carnegie William Ludington’s quest to understand the community ecology of our gut microbiome was this spring awarded nearly $1 million over three years from the National...
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Heart Reef in Australia's Great Barrier Reef, public domain.
Baltimore, MD— The CRISPR/Cas9 genome editing system can help scientists understand, and possibly improve, how corals respond to the environmental stresses of climate change. Work led by...
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Orange peyssonnelid algal crusts courtesy of Peter Edmunds.
Baltimore, MD—Human activity endangers coral health around the world. A new algal threat is taking advantage of coral’s already precarious situation in the Caribbean and making it even...
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Baltimore, MD— Recently published work from Carnegie’s Allan Spradling and Wanbao Niu revealed in unprecedented detail the genetic instructions immature egg cells go through step by step...
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Baltimore, MD— Recent work led by Carnegie’s Kamena Kostova revealed a new quality control system in the protein production assembly line with possible implications for understanding...
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Coral and legume roots. New staff scientists study symbiosis in these systems.
Baltimore, MD— Carnegie’s Department of Embryology welcomes two new Staff Scientists, both of whom specialize in researching the symbiotic relationships between species. Brittany Belin...
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Experimental zebrafish larvae, courtesy Navid Marvi.
Baltimore, MD—New work led by Carnegie’s Meredith Wilson and Steve Farber identifies a potential therapeutic target for clogged arteries and other health risks that stem from an excess of...
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In mammals, most lipids, such as fatty acids and cholesterol, are absorbed into the body via the small intestine. The complexity of the cells and fluids that inhabit this organ make it very difficult to study in a laboratory setting. The goal of the Farber lab is to better understand the cell and...
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The Zheng lab studies cell division including the study of stem cells, genome organization, and lineage specification. They study the mechanism of genome organization in development, homeostasis—metabolic balance-- and aging; and the influence of cell morphogenesis, or cell shape and...
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Approximately half of the gene sequences of human and mouse genomes comes from so-called mobile elements—genes that jump around the genome. Much of this DNA is no longer capable of moving, but is likely “auditioning”  perhaps as a regulator of gene function or in homologous...
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The mouse is a traditional model organism for understanding physiological processes in humans. Chen-Ming Fan uses the mouse to study the underlying mechanisms involved in human development and genetic diseases. He concentrates on identifying and understanding the signals that direct the...
Meet this Scientist
Yixian Zheng is Director of the Department of Embryology. Her lab has a long-standing interest in cell division. In recent years, their findings have broadened their research using animal models, to include the study of stem cells, genome organization, and lineage specification—how stem cells...
Meet this Scientist
Phillip Cleves’ Ph.D. research was on determining the genetic changes that drive morphological evolution. He used the emerging model organism, the stickleback fish, to map genetic changes that control skeletal evolution. Using new genetic mapping and reverse genetic tools developed during his...
Meet this Scientist
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Baltimore, MD — Insect glands are responsible for producing a host of secretions that allow bees to sting and ants to lay down trails to and from their nests. New research from Carnegie scientists...
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Baltimore, MD—Carnegie’s educational outreach program, BioEYES, will be the recipient of the 2012 Viktor Hamburger Outstanding Educator Prize from the Society for Developmental Biology. BioEYES...
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This week Carnegie’s Steve Farber will be recognized by New England Biolabs Inc. with its Passion in Science Award in the category of Mentorship and Advocacy. Farber co-founded a non-...
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Explore Carnegie Science

Artist's conception of this research project courtesy of Navid Marvi
July 14, 2021

Baltimore, MD—Carnegie’s Steven Farber was awarded nearly $500,000 over three years by The G. Harold & Leila Y. Mathers Foundation to identify the chemical components of cinnamon oil that show effectiveness against cardiovascular disease-causing fats.

Fat molecules, or lipids, such as cholesterol and triglycerides are shuttled around the circulatory system by a protein called Apolipoprotein-B, together forming complexes of lipid and protein that are called lipoproteins but may be more commonly known as “bad cholesterol.” It can get embedded in the sides of blood vessels and harden, forming a dangerous buildup that makes it more difficult for the heart

Carnegie's William Ludington
July 14, 2021

Baltimore, MD—Carnegie William Ludington’s quest to understand the community ecology of our gut microbiome was this spring awarded nearly $1 million over three years from the National Science Foundation. He was also selected as one of 14 researchers to receive $55,000 from the Research Corporation for Science Advancement for its inaugural Scialog: Microbiome, Neurobiology, and Disease initiative.

“Since he arrived at Carnegie in 2018, Will has been aggressively pursuing breakthroughs in microbiome research—deploying a multitude of genetic, physiological, and mathematical approaches,” said Carnegie Embryology Director Yixian Zheng. “These two

Heart Reef in Australia's Great Barrier Reef, public domain.
December 21, 2020

Baltimore, MD— The CRISPR/Cas9 genome editing system can help scientists understand, and possibly improve, how corals respond to the environmental stresses of climate change. Work led by Phillip Cleves—who joined Carnegie’s Department of Embryology this fall—details how the revolutionary, Nobel Prize-winning technology can be deployed to guide conservation efforts for fragile reef ecosystems.

Cleves’ research team’s findings were recently published in two papers in the Proceedings of the National Academy of Sciences.

Corals are marine invertebrates that build extensive calcium carbonate skeletons from which reefs are constructed. But this

Orange peyssonnelid algal crusts courtesy of Peter Edmunds.
November 30, 2020

Baltimore, MD—Human activity endangers coral health around the world. A new algal threat is taking advantage of coral’s already precarious situation in the Caribbean and making it even harder for reef ecosystems to grow.

Just-published research in Scientific Reports details how an aggressive, golden-brown, crust-like alga is rapidly overgrowing shallow reefs, taking the place of coral that was damaged by extreme storms and exacerbating the damage caused by ocean acidification, disease, pollution, and bleaching.

For the past four years, the University of Oxford’s Bryan Wilson, Carnegie’s Chen‑Ming Fan, and California State University Northridge’

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Approximately half of the gene sequences of human and mouse genomes comes from so-called mobile elements—genes that jump around the genome. Much of this DNA is no longer capable of moving, but is likely “auditioning”  perhaps as a regulator of gene function or in homologous recombination, which is a type of genetic recombination where the basic structural units of DNA,  nucleotide sequences, are exchanged between two DNA molecules to  repair  breaks in the DNA  strands. Modern mammalian genomes also contain numerous intact movable elements, such as retrotransposon LINE-1, that use RNA intermediates to spread about the genome. 

Given

The Spradling laboratory studies the biology of reproduction. By unknown means eggs reset the normally irreversible processes of differentiation and aging. The fruit fly Drosophila provides a favorable multicellular system for molecular genetic studies. The lab focuses on several aspects of egg development, called oogenesis, which promises to provide insight into the rejuvenation of the nucleus and surrounding cytoplasm. By studying ovarian stem cells, they are learning how cells maintain an undifferentiated state and how cell production is regulated by microenvironments known as niches. They are  also re-investigating the role of steroid and prostaglandin hormones in controlling

The Zheng lab studies cell division including the study of stem cells, genome organization, and lineage specification. They study the mechanism of genome organization in development, homeostasis—metabolic balance-- and aging; and the influence of cell morphogenesis, or cell shape and steructure,  on cell fate decisions. They use a wide range of tools and systems, including genetics in model organisms, cell culture, biochemistry, proteomics, and genomics.

 

In mammals, most lipids, such as fatty acids and cholesterol, are absorbed into the body via the small intestine. The complexity of the cells and fluids that inhabit this organ make it very difficult to study in a laboratory setting. The goal of the Farber lab is to better understand the cell and molecular biology of lipids within digestive organs by exploiting the many unique attributes of the clear zebrafish larva  to visualize lipid uptake and processing in real time.  Given their utmost necessity for proper cellular function, it is not surprising that defects in lipid metabolism underlie a number of human diseases, including obesity, diabetes, and atherosclerosis.

The mouse is a traditional model organism for understanding physiological processes in humans. Chen-Ming Fan uses the mouse to study the underlying mechanisms involved in human development and genetic diseases. He concentrates on identifying and understanding the signals that direct the musculoskeletal system to develop in the mammalian embryo. Skin, muscle, cartilage, and bone are all derived from a group of progenitor structures called somites. Various growth factors—molecules that stimulate the growth of cells—in the surrounding tissues work in concert to signal each somitic cell to differentiate into a specific tissue type.

The lab has identified various growth

The Donald Brown laboratory uses  amphibian metamorphosis to study complex developmental programs such as the development of vertebrate organs. The thyroid gland secretes thyroxine (TH), a hormone essential for the growth and development of all vertebrates including humans. To understand TH, director emeritus Donald Brown studies one of the most dramatic roles of the hormone, the control of amphibian metamorphosis—the process by which a tadpole turns into a frog. He studies the frog Xenopus laevis from South Africa.

 Events as different as the formation of limbs, the remodeling of organs, and the resorption of tadpole tissues such as the tail are all directed by TH

Staff Associate Kamena Kostova joined the Department of Embryology in November 2018. She studies ribosomes, the factory-like structures inside cells that produce proteins. Scientists have known about ribosome structure, function, and biogenesis for some time. But, a major unanswered question is how cells monitor the integrity of the ribosome itself. Problems with ribosomes have been associated with diseases including neurodegeneration and cancer. The Kostova lab investigates the fundamental question of how cells respond when their ribosomes break down using mass spectrometry, functional genomics methods, and CRISPR genome editing.

Kostova received a B.S. in Biology from the

Brittany Belin joined the Department of Embryology staff in August 2020. Her Ph.D. research involved developing new tools for in vivo imaging of actin in cell nuclei. Actin is a major structural element in eukaryotic cells—cells with a nucleus and organelles —forming contractile polymers that drive muscle contraction, the migration of immune cells to  infection sites, and the movement of signals from one part of a cell to another. Using the tools developed in her Ph.D., Belin discovered a new role for actin in aiding the repair of DNA breaks in human cells caused by carcinogens, UV light, and other mutagens.

Belin changed course for her postdoctoral work, in