Genetics & Developmental Biology Stories
Baltimore, MD—A newly developed technique that shows artery clogging fat-and-protein complexes in live fish gave investigators from Carnegie, Johns Hopkins University, and the Mayo Clinic a...
Baltimore, MD—How do the communities of microbes living in our gastrointestinal systems affect our health? Carnegie’s Will Ludington was part of a team that helped answer this question....
Meredith Wilson, a postdoctoral associate in Steve Farber’s lab at the Department of Embryology, has been awarded Carnegie’s thirteenth Postdoctoral Innovation and Excellence Award. These...
Washington, DC—Aging-related inflammation can drive the decline of a critical structural protein called lamin-B1, which contributes to diminished immune function in the thymus, according to...
Baltimore, MD—This week Carnegie’s Steve Farber will be recognized by New England Biolabs Inc. with its Passion in Science Award in the category of Mentorship and Advocacy. The company,...
Baltimore, MD—Michael Diamreyan, a Johns Hopkins University undergraduate biophysics student with a Carnegie connection, has been awarded two prestigious research grants to further his...
Baltimore, MD—The interactions that take place between the species of microbes living in the gastrointestinal system often have large and unpredicted effects on health, according to new work...
Baltimore, MD—Since Carnegie Institution’s Barbara McClintock received her Nobel Prize on her discovery of jumping genes in 1983, we have learned that almost half of our DNA is made up of...
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The Marnie Halpern laboratory studies how left-right differences arise in the developing brain and discovers the genes that control this asymmetry. Using the tiny zebrafish, Danio rerio, they explores how regional specializations occur within the neural tube, the embryonic tissue that develops into...
The Spradling laboratory studies the biology of reproduction. By unknown means eggs reset the normally irreversible processes of differentiation and aging. The fruit fly Drosophila provides a favorable multicellular system for molecular genetic studies. The lab focuses on several aspects of egg...
The Gall laboratory studies all aspects of the cell nucleus, particularly the structure of chromosomes, the transcription and processing of RNA, and the role of bodies inside the cell nucleus, especially the Cajal body (CB) and the histone locus body (HLB).
Much of the work makes use of the giant...
In mammals, most lipids, such as fatty acids and cholesterol, are absorbed into the body via the small intestine. The complexity of the cells and fluids that inhabit this organ make it very difficult to study in a laboratory setting. The goal of the Farber lab is to better understand the cell and...
The Ludington lab investigates complex ecological dynamics from microbial community interactions using the fruit fly Drosophila melanogaster. The fruit fly gut carries numerous microbial species, which can be cultured in the lab. The goal is to understand the gut ecology...
The first step in gene expression is the formation of an RNA copy of its DNA. This step, called transcription, takes place in the cell nucleus. Transcription requires an enzyme called RNA polymerase to catalyze the synthesis of the RNA from the DNA template. This, in addition to other processing...
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Baltimore, MD— The ability of embryonic stem cells to differentiate into different types of cells with different functions is regulated and maintained by a complex series of chemical interactions,...
Using the CRISPR/Cas9 genome-editing tool, biologists can now target specific genes for mutation and then see how this induced mutation manifests in an organism. But sometimes an organism compensates...
AudioBaltimore, MD—Proper tissue function and regeneration is supported by stem cells, which reside in so-called niches. New work from Carnegie’s Yixian Zheng and Haiyang Chen identifies an important...
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