The NASA Astrobiology Institute (NAI) Carnegie Team focuses on life’s chemical and physical evolution, from the interstellar medium, through planetary systems, to the emergence and detection of life by studying extrasolar planets, Solar System formation, organic rich primitive planetary bodies, prebiotic molecular synthesis through catalyzing with minerals, and the connection between planetary evolution to the emergence, and sustenance of biology. This program attempts to integrate the sweeping narrative of life’s history through a combination of bottom-up and top-down studies. On the one hand, this team studies processes related to chemical and physical evolution in plausible prebiotic environments – circumstellar disks—discs of dust and gas around stellar systems, extrasolar planetary systems and the primitive Earth. The teams is also documenting the nature of microbial life at extreme conditions, as well as the characterization of organic matter in ancient fossils. These efforts are important to developing biotechnological approaches to life detection on other worlds.